微小RNA调控巨噬细胞表型及功能在肿瘤进展中的作用  

Role of microRNAs in tumor progression by regulating macrophage phenotypes and functions

作　　者：潘丰彦 刘倩倩(综述) 刘芳[1] 陈彻(审校)[1] PAN Fengyan;LIU Qianqian;LIU Fang;CHEN Che(Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000

出　　处：《中国生物制品学杂志》2023年第8期1002-1004,1009,共4页Chinese Journal of Biologicals

基　　金：甘肃省科技计划项目(20JR10RA311);兰州市城关区科技计划项目(2020JSCX0084);甘肃省高等学校科研项目(2017A-051)。

摘　　要：微小RNA(microRNAs,miRNAs)是一类单链非编码小分子RNA,调控包括肿瘤在内的许多疾病的发病过程。巨噬细胞作为肿瘤微环境(tumor microenvironment,TME)中主要渗透免疫细胞,其在肿瘤的起始、血管生成、转移、耐药性等方面均发挥重要作用。miRNAs表达的改变可能会调节巨噬细胞功能,从而影响肿瘤发展过程。本文对miRNAs通过调控巨噬细胞表型和功能从而影响肿瘤进展的相关机制作一综述,为肿瘤治疗提供新的思路。MicroRNAs(miRNAs) are a class of small non-coding RNAs that regulate the pathogenesis of many diseases,including cancer. As the main permeable immune cells in the tumor microenvironment(TME),macrophages play an important role in tumor initiation,angiogenesis,metastasis,drug resistance and so on. The altered expression of miRNAs may regulate the function of macrophages and thus affect the progression of cancer. This paper reviews the mechanism of miRNAs influencing tumor progression by regulating the phenotype and function of macrophages,and provides a new idea for tumor treatment.

关 键 词：巨噬细胞 微小RNA 外泌体 肿瘤 

分 类 号：R730.3[医药卫生—肿瘤]