青少年不同分类高度近视患眼黄斑区浅层视网膜血流密度及相关因素分析  

Superficial retinal blood flow density analysis and related factors in adolescents with different classificationofhighmyopia

作　　者：吉艳艳 王甲 张士玺 陈松 Ji Yanyan;Wang Jia;Zhang Shix;Chen Song(Clinical College of Ophthalmology,Tianjin Medical University,Tianjin 300020,China;Tian Eye Hospital,Tianjin 300020,China;Liaocheng Aier Eye Hospital,Liaocheng 252100,China;Dezhou Aier Eye Hospital,Dezhou 253000,China)

机构地区：[1]天津医科大学眼科临床学院,天津300020 [2]天津市眼科医院,天津300020 [3]聊城爱尔眼科医院,山东省聊城市252100 [4]德州爱尔眼科医院,山东省德州市253000

出　　处：《中华眼底病杂志》2023年第8期649-656,共8页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察并分析青少年不同类型非病理性高度近视(HM)患眼黄斑区浅层视网膜血流密度及其相关影响因素。方法回顾性临床研究。2022年3~8月因近视就诊于聊城爱尔眼科医院的青少年117名117只眼纳人研究。根据等效球镜度(SE)和角膜曲率,将受检者分为轻度近视或正视眼组(对照组)、HM组、隐匿性HM(OHM)组、超HM(SHM)组,分别为30名30只眼、28名28只眼、35名35只眼、24名24只眼。受检者均行医学验光、眼压、光相干断层扫描(OCT)、OCT血管成像(OCAT)检查以及眼轴长度(AL)、角膜曲率测量。屈光度数以SE表示。采用OCTA仪对受检眼黄斑区6mm×6mm范围进行扫描,软件自动将其划分为以黄斑中心凹为中心的3个同心圆,分别是直径1mm的中心区,1~3mm的内环区,3~6mm的外环区。测量黄斑区整体及不同分区浅层视网膜血流密度(SRVD)、浅层视网膜血流灌注密度(SBPD)以及黄斑中心凹无血管区(FAZ)面积、周长(PERIM)、非圆度指数(AI)、视网膜厚度。多组间数据比较采用单因素方差分析;组间两两比较采用最小显著差法检验。AL、角膜曲率、眼压与黄斑各区域SRVD、SBPD的相关性采用Pearson相关性分析。结果对照组、HM组、OHM组、SHM组受检眼黄斑区整体以及中心区、内环区、外环区SRVD、SBPD比较,差异均有统计学意义(P<0.05);中心区以及外环区上方、下方、侧视网膜厚度比较,差异均有统计学意义(P<0.05),鼻侧视网膜厚度比较,差异无统计学意义(P>0.05);PERIM比较,差异无统计学意义(P>0.05);FAZ面积、AI比较,差异有统计学意义(P<0.05)。相关性分析结果显示,AL与黄斑区整体及中心区、内环区、外环区SRVD、SBPD呈负相关(P<0.05);角膜曲率、SE与黄斑区整体及中心区、外环区SRVD、SBPD呈正相关性(P<0.05)。AL与外环区各区域视网膜厚度呈负相关(P<0.05);SE与外环区上方、下方、侧视网膜厚度呈正相关(P<0.05)。AL与FAZ面积、AObjectiveTo observe and analyze the superficial retinal blood flow density and its related influencing factors in the macular area of adolescents with different types of non-pathological high myopia(HM).Methods A retrospective clinical study.From March to August 2022,117 eyes of 117 adolescents who were admitted to Liaocheng Aier Eye Hospital due to myopia were included in the study.According to equivalent spherical degree(SE)and corneal curvature,subjects were divided into mild myopia or emmetropia group(control group),HM group,occult HM(OHM)group,and super HM(SHM)group,with 30 eyes,28 eyes,35 eyes,and 24 eyes,respectively.All subjects underwent medical optometry,intraocular pressure,optical coherence tomography(OCT),OCT angiography(OCTA),axial length(AL)and corneal curvature measurements.The diopter was SE.OCTA instrument was used to scan the macular region in the range of 6 mm×6 mm,and the software automatically divided it into three concentric circles centered on the fovea of the macular,namely,the central area with a diameter of 1 mm,the inner ring area with a diameter of 1-3 mm,and the outer ring area with a diameter of 3-6 mm.The superficial retinal vascular density(SRVD),vascular perfusion density(SBPD),the area,perimeter(PERIM),avascular index(AI)of foveal avascular area(FAZ)and retinal thickness were measured in the macular region as a whole and in different regions.One-way analysis of variance was used to compare the data among groups,and the least significant difference t-test was used to compare the data among groups.The correlation of AL,corneal curvature and intraocular pressure with SRVD and SBPD in macula was analyzed by Pearson correlation analysis.Results There were significant differences in SRVD and SBPD in the central,inner and outer regions of macula in control group,HM group,OHM group and SHM group(P<0.05).There were statistically significant differences in the thickness of the retina above,below and on the temporal side of the central and outer ring regions(P<0.05).However,no statistical

关 键 词：普通高度近视 隐匿性高度近视 超高度近视 黄斑区浅层视网膜血流密度 视网膜厚度 

分 类 号：R778.11[医药卫生—眼科]