盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎患者的临床疗效及安全性分析  

Clinical efficacy and safety analysis of minocycline hydrochloride ointment combined with tinidazole in the treatment of chronic periodontitis

作　　者：许艳艳 荣博 贺薷葳 XU Yanyan;RONG Bo;HE Ruwei(Department of Stomatology,Yingkou Central Hospital,Yingkou,Liaoning,115005,China)

机构地区：[1]营口市中心医院口腔科,辽宁营口115005

出　　处：《当代医学》2023年第6期59-62,共4页Contemporary Medicine

摘　　要：目的分析盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎(CP)患者的临床疗效及安全性。方法选取2018年6月至2020年6月营口市中心医院接诊的100例CP患者作为研究对象,按照随机数字表法分为两组,每组50例。对照组给予盐酸米诺环素软膏治疗,观察组在对照组基础上联合替硝唑治疗,比较两组炎症因子水平、牙周指标、临床疗效及不良反应发生率。结果治疗前,两组可溶性细胞间黏附分子-1(sICAM-1)、白细胞介素-1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1)水平比较差异无统计学意义;治疗后,两组sICAM-1、IL-1β、MCP-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组牙菌斑指数(PLI)、牙龈指数(GI)评分和牙周袋探诊深度(PPD)比较差异无统计学意义;治疗后,两组PLI、GI评分均低于治疗前,PPD浅于治疗前,且观察组PLI、GI评分均低于对照组,PPD浅于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为94.00%,高于对照组的78.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论盐酸米诺环素软膏联合替硝唑治疗CP患者疗效显著,可改善患者牙周状况及临床症状,且能减轻牙周炎症反应,安全性较高,值得临床推广应用。Objective To analyze the clinical efficacy and safety of minocycline hydrochloride ointment combined with tinidazole in the treatment of chronic periodontitis(CP).Methods 100 patients with CP admitted to Yingkou Central Hospital from June 2018 to June 2020 were selected as the study subjects,and they were divided into two groups according to the random number table method,with 50 cases in each group.The control group was treated with minocycline hydrochloride ointment,and the observation group was treated with tinidazole on the basis of the control group,the levels of inflammatory factors,periodontal indicators,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in the levels of soluble intercellular adhesion molecule-1(sICAM-1),interleukin-1β(IL-1β)and monocyte chemotactic protein-1(MCP-1)between the two groups;after treatment,the levels of sICAM-1 and IL-1βand MCP-1 of two groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of plaque index(PLI),gingival index(GI)and eriodontal pocket probing depth(PPD)between the two groups;after treatment,the scores of PLI and GI of the two groups were lower than those before treatment,and the PPD was shallower than that before treatment,and the scores of PLI and GI in the observation group were lower than those in the control group,and the PPD was shallower than that in the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 94.00%,which was higher than 78.00%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Minocycline hydrochloride ointment combined with tinidazole is

关 键 词：盐酸米诺环素软膏 替硝唑 慢性牙周炎 炎症因子 安全性 

分 类 号：R781.42[医药卫生—口腔医学]