维生素C联合奥曲肽在改良经颈内静脉肝内门体分流术治疗门静脉高压急性上消化道出血患者中的临床疗效  

Clinical efficacy of vitamin C combined with octreotide in modified trantrajugular intrahepatic portosystemic shunt in patients with acute upper gastrointestinal bleeding with portal hypertension

作　　者：孔凡荣[1] 李巍[2] 冯丹[3] KONG Fanrong;LI Wei;FENG Dan(Digestive Department 1,Jinzhou Central Hospital,Jinzhou,Liaoning,121000,China;Department of Oncology,Jinzhou Central Hospital,Jinzhou,Liaoning,121000,China;Department of General Surgery,Jinzhou Central Hospital,Jinzhou,Liaoning,121000,China)

机构地区：[1]锦州市中心医院消化一科,辽宁锦州121000 [2]锦州市中心医院肿瘤科,辽宁锦州121000 [3]锦州市中心医院普外科,辽宁锦州121000

出　　处：《当代医学》2023年第6期142-144,共3页Contemporary Medicine

摘　　要：目的探讨维生素C联合奥曲肽在改良经颈内静脉肝内门体分流术(TIPS)治疗门静脉高压急性上消化道出血患者中的临床疗效。方法选取2019年6月至2021年6月于本院行改良TIPS治疗的54例门静脉高压急性上消化道出血患者作为研究对象,按照给药方案不同分为对照组和实验组,每组27例。对照组给予单纯奥曲肽治疗,实验组给予维生素C联合奥曲肽治疗,比较两组止血有效率、凝血指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶原时间(APTT)]及不良反应发生情况。结果实验组止血有效率为100.00%,高于对照组的74.07%,差异有统计学意义(P<0.05)。治疗3 d后,实验组PT、TT、APTT均短于对照组,差异有统计学意义(P<0.05)。实验组不良反应发生率为18.52%,高于对照组的11.11%,但差异无统计学意义。结论维生素C联合奥曲肽应用于改良TIPS治疗门静脉高压急性上消化道出血患者中效果显著,可改善患者凝血功能,降低机体氧化应激反应,且不增加不良反应,值得临床推广应用。Objective To investigate the clinical efficacy of vitamin C combined with octreotide in modified transjugular intrahepatic portosystemic shunt(TIPS)in patients with acute upper gastrointestinal bleeding with portal hypertension.Methods 54 patients with acute upper gastrointestinal bleeding with portal hypertension who received modified TIPS treatment in our hospital from June 2019 to June 2021 were selected as the research subjects,and they were divided into control group and experimental group according to different dosing regimens,with 27 cases in each group.The control group was treated with octreotide alone,the experimental group was treated with vitamin C combined with octreotide,the hemostatic effective rate,coagulation index(prothrombin time[PT],thrombin time[TT],activated partial prothrombin time[APTT]),and the occurrence of adverse reactions were compared between the two groups.Results The hemostasis effective rate in the experimental group was 100.00%,which was higher than 74.07%in the control group,and the difference was statistically significant(P<0.05).After 3 d of treatment,the PT,TT and APTT in the experimental group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 18.52%,which was higher than 11.11%in the control group,but there was no statistically significant difference.Conclusion The application of vitamin C combined with octreotide in modified TIPS the treatment of patients with acute upper gastrointestinal bleeding with portal hypertension has significant effect,which can improve the coagulation function of patients,reduce the oxidative stress reaction,and not increase the adverse reactions,which is worthy of clinical promotion and application.

关 键 词：维生素C 奥曲肽 改良经颈内静脉肝内门体分流术 门静脉高压 急性上消化道出血 

分 类 号：R573.2[医药卫生—消化系统]