促甲状腺激素受体与人乳头瘤病毒16 E6蛋白在宫颈癌组织中的表达及其与临床病理特征的关系  

Expression of thyrotropin receptor and human papillomavirus 16 E6 protein in cervical cancer and their relationship with clinicopathological characteristics

作　　者：李敏 张君 蔡婷婷 LI Min;ZHANG Jun;CAI Tingting(Department of Obstetrics and Gynecology,Shenyang Jishuitan Hospital,Shenyang,Liaoning,110000,China)

机构地区：[1]沈阳积水潭医院妇产科,辽宁沈阳110000

出　　处：《当代医学》2023年第19期59-62,共4页Contemporary Medicine

摘　　要：目的探究促甲状腺激素受体(TSHR)、人乳头瘤病毒(HPV)16 E6蛋白在宫颈癌组织中的表达及其与临床病理特征的关系。方法选取2016年1月至2018年3月本院收治的124例宫颈癌患者作为研究对象,分别采集所有受试者的宫颈癌组织、癌旁组织及正常组织,采用免疫组织化学法检测不同宫颈组织的TSHR、HPV16 E6蛋白表达情况。比较不同宫颈组织中TSHR、HPV16 E6蛋白阳性率,分析TSHR、HPV16 E6蛋白表达与宫颈癌患者临床病理特征及生存状况的关系。结果宫颈癌组织中TSHR、HPV16 E6蛋白阳性率(67.74%、66.13%)均高于癌旁组织(21.77%、22.58%)及正常组织(2.42%、3.23%),且癌旁组织高于正常组织,差异有统计学意义(P<0.05)。低分化、肿瘤直径≥3 cm及有淋巴结转移宫颈癌患者TSHR蛋白阳性率均高于中高分化、肿瘤直径<3 cm及无淋巴结转移宫颈癌患者,差异有统计学意义(P<0.05);不同年龄、临床分期宫颈癌患者TSHR蛋白阳性率比较差异无统计学意义。年龄≥60岁、有淋巴结转移宫颈癌患者HPV16 E6蛋白阳性率均高于年龄<60岁、无淋巴结转移宫颈癌患者,差异有统计学意义(P<0.05);不同临床分期、分化程度、肿瘤直径宫颈癌患者HPV16 E6蛋白阳性率比较差异无统计学意义。随访3年,124例宫颈癌患者中,死亡74例,存活50例;宫颈癌死亡患者TSHR蛋白阳性率高于存活患者,差异有统计学意义(P<0.05),而宫颈癌死亡患者与存活患者HPV16 E6蛋白阳性率比较差异无统计学意义。结论宫颈癌组织中TSHR、HPV16 E6蛋白均存在异常高表达,其中TSHR蛋白表达与宫颈癌患者分化程度、肿瘤直径、淋巴结转移及预后有关,HPV16 E6蛋白表达与宫颈癌患者年龄及淋巴结转移密切相关,而与预后无关。Objective To investigate the expression of thyrotropin receptor(TSHR)and human papilloma virus(HPV)16 E6 protein in cervical cancer and their relationship with clinicopathological characteristics.Methods 124 patients with cervical cancer admitted to our hospital from January 2016 to March 2018 were selected as the research subjects,cervical cancer tissue,adjacent tissue,and normal tissue of all subjects were collected,and the expression of TSHR and HPV16 E6 proteins in different cervical tissues was detected by immunohistochemistry.The positive rates of TSHR and HPV16 E6 proteins in different cervical tissues were compared,and the relationship between the expression of TSHR,HPV16 E6 protein and the clinical pathological characteristics and survival status of patients with cervical cancer were analyzed.Results The positive rates of TSHR and HPV16 E6 proteins in cervical cancer tissues(67.74%,66.13%)were higher than those in adjacent tissues(21.77%,22.58%)and normal tissues(2.42%,3.23%),and paracarcinoma tissues were higher than normal tissues,the differences were statistically significant(P<0.05).The positive rate of TSHR protein in cervical cancer patients with poorly differentiated,tumor diameter≥3 cm,and with lymph node metastasis were higher than those in cervical cancer patients with moderately well differentiated,tumor diameter<3 cm,and cervical cancer without lymph node metastasis,the differences were statistically significant(P<0.05);there was no significant difference in the positive rate of TSHR protein in cervical cancer patients of different ages and clinical stages.The positive rate of HPV16 E6 protein in cervical cancer patients aged≥60 years and with lymph node metastasis was higher than that in cervical cancer patients aged<60 years and without lymph node metastasis,and the differences were statistically significant;there was no significant difference in the positive rate of HPV16 E6 protein in patients with different clinical stage,differentiation degree and tumor diameter.(P<0.05).Follow-up o

关 键 词：宫颈癌 促甲状腺激素受体 人乳头瘤病毒 临床病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]