冰片联合TP方案治疗晚期三阴性乳腺癌脑转移疗效分析  

Efficacy of borneol combined with TP regimen in the treatment of advanced triple-negative breast cancer with brain metastases

作　　者：石玲[1] 梅耀国 段训凰[1] SHI Ling;MEI Yaoguo;DUAN Xunhuang(Department of Oncology,The First People's Hospital of Jiujiang,Jiujiang,Jiangxi,332001,China;Department of Oncology,Jiujiang Traditional Chinese Medicine Hospital,Jiujiang,Jiangxi,332099,China)

机构地区：[1]九江市第一人民医院肿瘤科,江西九江332001 [2]九江市中医医院肿瘤科,江西九江332099

出　　处：《当代医学》2023年第13期47-50,共4页Contemporary Medicine

基　　金：江西省中医药管理局科技计划(2020A0127)。

摘　　要：目的探讨冰片联合TP(紫杉醇+顺铂)方案治疗晚期三阴性乳腺癌(TNBC)脑转移的疗效。方法选取2016年1至2020年1月本院收治的54例晚期TNBC脑转移患者作为研究对象,随机分为对照组与实验组,每组27例。对照组采用TP方案治疗,实验组在对照组基础上联合冰片治疗,比较两组临床疗效、肿瘤标志物[糖类抗原153(CA153)、糖类抗原125(CA125)]、不良反应发生率及术后生存情况[无进展生存期(PFS)、总生存期(OS)]。结果实验组临床疗效优于对照组,疾病控制率(DCR)高于对照组,差异有统计学意义(P<0.05);两组客观有效率(ORR)比较差异无统计学意义。治疗前,两组CA153、CA125水平比较差异无统计学意义;治疗2个周期后,两组CA153、CA125水平均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05)。两组胃肠道反应、骨髓抑制、心脏毒性及肝肾功能损害发生率比较差异无统计学意义。随访12个月后,两组PFS比较差异无统计学意义;实验组OS长于对照组,差异有统计学意义(P<0.05)。结论冰片联合TP方案治疗晚期TNBC脑转移患者可增强治疗效果,降低肿瘤标志物水平,且安全性较高,可延长OS,值得临床推广应用。Objective To investigate the efficacy of borneol combined with TP regimen(paclitaxel+cisplatin)in the treatment of advanced triplenegative breast cancer(TNBC)with brain metastases.Methods 54 patients with advanced TNBC with brain metastases admitted to our hospital from January 2016 to January 2020 were selected as the study subjects,and they were randomly divided into the control group and the experimental group,with 27 cases in each group.The control group was treated with TP regimen,and the experimental group was combined with borneol on the basis of the control group the clinical efficacy,tumor markers(carbohydrate antigen 153[CA153],carbohydrate antigen 125[CA125]),incidence of adverse reactions and postoperative survival(progressives-free survival[PFS],overall survival[OS])were compared between the two groups.Results The clinical efficacy of the experimental group was better than that in the control group,and the disease control rate(DCR)was higher than that in the control group,the differences were statistically significant(P<0.05);there was no significant difference in objective response rate(ORR)between the two groups.Before treatment,there were no significant differences in CA153 and CA125 levels between the two groups;after 2 cycles of treatment,CA153 and CA125 levels in of the two groups were lower than before treatment,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).There were no significant differences in the incidence of gastrointestinal reactions,bone marrow suppression,cardiotoxicity and liver and kidney function impairment between the two groups.After 12 months of follow-up,there was no significant difference in PFS between the two groups;OS in the experimental group was longer than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Borneol combined with TP regimen in the treatment of patients with advanced TNBC with brain metastases can enhance the therapeutic effect,reduce the level of

关 键 词：三阴性乳腺癌 顺铂 紫杉醇 冰片 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]