血清胃蛋白酶原联合肿瘤标志物检验在早期胃癌诊断中的应用价值  

Application value of serum pepsinogen combined with tumor marker test in diagnosis of early gastric cancer

作　　者：黄小平 龚亭丹 许娜 HUANG Xiaoping;GONG Tingdan;XU Na(Clinical Laboratory,Fuzhou First Hospital of Traditional Chinese Medicine,Fuzhou,Jiangxi,344000,China)

机构地区：[1]抚州市第一中医医院检验科,江西抚州344000

出　　处：《当代医学》2023年第13期123-125,共3页Contemporary Medicine

基　　金：抚州市指导性科技计划项目(抚科计字[2020]10号,第4项)。

摘　　要：目的探讨血清胃蛋白酶原联合肿瘤标志物检验在早期胃癌诊断中的应用价值。方法选取2018年6月至2021年6月本院收治的160例疑似早期胃癌患者作为研究对象,以病理检查为金标准,根据诊断结果分为胃癌组(n=105)与良性组(n=55),另选取同期80名健康人员作为对照组。所有受检者均检测胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、癌胚抗原(CEA)水平,统计病理检查结果,分析血清胃蛋白酶原联合肿瘤标志物的诊断效能,比较3组血清胃蛋白酶原与肿瘤标志物水平。结果160疑似胃癌受检者中,经病理学诊断确诊早期胃癌105例,占比65.63%,为胃癌淋巴结转移;胃良性病变患者55例,占比34.38%。血清胃蛋白酶原联合肿瘤标志物检测诊断早期胃癌准确率为88.13%、灵敏度为89.52%、特异度为85.45%、阴性预测值为81.03%及阳性预测值为92.16%。3组血清PGⅠ、PGⅡ、CA19-9、CA125、CEA水平比较差异有统计学意义(P<0.05);胃癌组CA19-9、CA125、CEA水平均高于良性组及对照组,PGⅠ、PGⅡ水平均低于良性组及对照组,且良性组CA19-9、CA125、CEA水平均高于对照组,PGⅠ、PGⅡ水平均低于对照组,差异有统计学意义(P<0.05)。结论血清胃蛋白酶原联合肿瘤标志物检验在早期胃癌诊断中的应用效果显著,具有较高的诊断准确率、灵敏度及特异度,可准确诊断早期胃癌,有效区分胃部其他病变,为疾病的早期治疗提供依据。Objective To explore the application value of serum pepsinogen combined with tumor marker test in the diagnosis of early gastric cancer.Methods 60 patients with suspected early gastric cancer admitted to our hospital from June 2018 to June 2021 were selected as the research subjects,based on the pathological examination as the gold standard,they were divided into the gastric cancer group(n=105)and the benign group(n=55)according to the diagnosis results,and 80 healthy people in the same period were selected as the control group.The levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)were detected in all subjects,and the diagnostic efficacy of serum pepsinogen combined with tumor markers was analyzed,the levels of serum pepsinogen and tumor markers were compared among the three groups.Results Among the 160 suspected gastric cancer patients,105 cases of early gastric cancer were confirmed by pathological diagnosis,accounting for 65.63%,which was gastric cancer lymph node metastasis;there were 55 cases with benign gastric lesions,accounting for 34.38%.The accuracy,sensitivity,specificity,negative predictive value and positive predictive value of serum pepsinogen combined with tumor markers in the diagnosis of early gastric cancer were 88.13%,89.52%,85.45%,81.03%and 92.16%,respectively.There were significant differences in the serum levels of PGⅠ,PGⅡ,CA19-9,CA125 and CEA among the three groups(P<0.05);the levels of CA19-9,CA125 and CEA in the gastric cancer group were higher than those in the benign group and control group,and the levels of PGⅠand PGⅡwere lower than those in the benign group and the control group,and the levels of CA19-9,CA125 and CEA in the benign group were higher than those in the control group,and the levels of PGⅠand PGⅡwere lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of serum pepsinogen combined with tumor m

关 键 词：早期胃癌 胃良性病变 胃蛋白酶 肿瘤标志物 诊断效能 

分 类 号：R735.2[医药卫生—肿瘤]