依达拉奉联合长春西汀注射液治疗急性脑出血的临床疗效及对患者神经功能的影响  

Clinical efficacy of edaravone combined with vinpocetine injection in the treatment of acute cerebral hemorrhage and its impact on neurological function in patients

作　　者：付美玲 FU Meiling(Third Department of Neurology,Fuxin Second People's Hospital/Fuxin Maternity and Obstetrics Hospital,Fuxin,Liaoning,123000,China)

机构地区：[1]阜新市第二人民医院/阜新市妇产医院神经内科三,辽宁阜新123000

出　　处：《当代医学》2023年第16期132-135,共4页Contemporary Medicine

摘　　要：目的探讨依达拉奉联合长春西汀注射液治疗急性脑出血的临床疗效及对患者神经功能的影响。方法选取2019年1月至2020年9月本院收治的141例急性脑出血患者作为研究对象,按照治疗方法不同分为单用组(n=69)与联用组(n=72),单用组采用长春西汀注射液治疗,联用组在单用组基础上联合依达拉奉治疗,比较两组神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、临床疗效、血清相关指标[B型利钠肽(BNP)、一氧化氮(NO)、丙二醛(MDA)]。结果治疗前,两组NIHSS评分比较差异无统计学意义;治疗后,两组NIHSS评分均低于治疗前,且联用组低于单用组,差异有统计学意义(P<0.05)。联用组治疗总有效率为93.06%,高于单用组的81.16%,差异有统计学意义(P<0.05)。治疗前,两组BNP、NO、MDA水平比较差异无统计学意义;治疗后,两组BNP、NO、MDA水平均低于治疗前,且联用组低于单用组,差异有统计学意义(P<0.05)。结论依达拉奉联合长春西汀注射液治疗急性脑出血的疗效显著,能有效改善患者受损的神经元,调节机体神经因子浓度,改善患者脑部血液循环,值得临床推广应用。Objective To investigate the clinical efficacy of edaravone combined with vinpocetine injection in the treatment of acute cerebral hemorrhage and its impact on neurological function in patients.Methods A total of 141 patients with acute cerebral hemorrhage admitted to our hospital from January 2019 to September 2020 were selected as the research subjects,they were divided into single use group(n=69)and combined use group(n=72)according to different treatment methods.The single use group was treated with vinpocetine injection,while the combined use group was treated with edaravone on the basis of the single use group,the neurological function(National Institute of Health stroke scale[NIHSS]score),clinical efficacy,serum related indicators(B natriuretic peptide[BNP],nitric oxide[NO],malondialdehyde[MDA]).Results Before treatment,there was no significant difference in NIHSS scores between the two groups;after treatment,the NIHSS scores of two groups were lower than before treatment,and the combined group was lower than the single group,the difference was statistically significant(P<0.05).The total effective rate in the combined treatment group was 93.06%,which was higher than 81.16%in the single use group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of BNP,NO,and MDA between the two groups;after treatment,the levels of BNP,NO,and MDA of the two groups were lower than before treatment,and the combined use group was lower than the single use group,the differences were statistically significant(P<0.05).Conclusion Edaravone combined with vinpocetine injection has significant therapeutic effect on acute cerebral hemorrhage,which can effectively improve the injured neurons in patients,regulate the concentration of neurotrophic factors in the body,and improve the cerebral blood circulation in patients,it is worthy of clinical promotion and application.

关 键 词：依达拉奉 神经功能 血液循环 长春西汀注射液 急性脑出血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]