丁苯酞联合替罗非班治疗对进展性脑卒中患者颅内外血管狭窄的影响  

Effect on intracranial and extracranial vascular stenosis in patients with progressive stroke treated by butylphthalide combined with tirofiban

作　　者：李翠平[1] 胡薇薇[1] 王薇[1] LI Cuiping;HU Weiwei;WANG Wei(Department of Neurology,Nanyuan Hospital,Fengtai District,Beijing,100076,China)

机构地区：[1]北京市丰台区南苑医院神经内科,北京100076

出　　处：《当代医学》2023年第18期174-176,共3页Contemporary Medicine

摘　　要：目的探讨丁苯酞联合替罗非班治疗对进展性脑卒中(PS)患者颅内外血管狭窄的影响。方法选取2019年6月至2020年6月于本院神经内科住院治疗的138例PS合并颅内外血管狭窄患者作为研究对象,采用抽签法分为联合组与对照组,每组69例。两组均给予常规治疗,对照组给予丁苯酞治疗,联合组在对照组的基础上联合替罗非班治疗,比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)、动脉狭窄改善时间及治疗前后血管狭窄程度、治疗后3个月内并发症发生情况及预后情况。结果治疗后,两组NIHSS评分均低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。联合组动脉狭窄改善时间短于对照组,差异有统计学意义(P<0.05)。治疗后,联合组血管狭窄程度明显轻于对照组,差异有统计学意义(P<0.05)。治疗3个月,联合组并发症发生率低于对照组,差异有统计学意义(P<0.05)。联合组预后良好率明显高于对照组,差异有统计学意义(P<0.05)。结论替罗非班联合丁苯酞治疗PS合并颅内外血管狭窄患者效果显著,可有效改善神经功能缺损,减轻颅内外血管狭窄,改善预后,值得临床推广应用。Objective To investigate the effect on intracranial and extracranial vascular stenosis in patients with progressive stroke(PS)treated by butylphthalide combined with tirofiban.Methods 138 patients with PS complicated with intracranial and extracranial vascular stenosis were admitted to the Neurology department of our hospital from Jun 2019 to Jun 2020 were selected as the research subjects,they were divided into the combination group and the control group according to drawing lots method,with 69 cases in each group.The two groups were treated with routine therapy,the control group was treated with butylphthalide,and the combination group was treated with tirofiban on the basis of the control group,the changes of National Institute of Health stroke scale(NIHSS)before and after treatment,the improvement time of arterial stenosis,the degree of vascular stenosis before and after treatment,the occurrence of complications within 3 months after treatment and the prognosis were compared between the two groups.Results After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the combined group was lower than the control group,the differences were statistically significant(P<0.05).The improvement time of arterial stenosis in the combination group was shorter than that in the control group,the difference was statistically significant(P<0.05).After treatment,the degree of vascular stenosis in the combination group was significantly lighter than that in the control group,the difference was statistically significant(P<0.05).3 months after treatment,the incidence of complications in the combination group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The rate of good prognosis in the combination group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Tirofiban combined with butylphthalide is effective in the treatment of PS with intracranial and extracranial vascu

关 键 词：丁苯酞 替罗非班 进展性脑卒中 颅内外血管狭窄 

分 类 号：R743.3[医药卫生—神经病学与精神病学]