减毒沙门菌在肿瘤治疗中的研究进展  

Progress on attenuated Salmonella typhimurium in the treatment of tumors

作　　者：尹艳梅 李俊峰 彭磊 阮万百 朱克祥[2] YIN Yanmei;LI Junfeng;PENG Lei;RUAN Wanbai;ZHU Kexiang(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,P.R.China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,P.R.China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院普外科,兰州730000

出　　处：《中国普外基础与临床杂志》2023年第8期988-994,共7页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金项目(项目编号:81960516)。

摘　　要：目的 概述减毒沙门菌的主要抗肿瘤作用机制,并对减毒沙门菌临床应用受限的可能原因进行探索。方法 查阅近年来国内外减毒沙门菌肿瘤治疗和毒力作用相关临床和基础研究的相关文献,就减毒沙门菌肿瘤治疗相关机制进行总结,并根据减毒沙门菌和人体免疫微环境的特点对减毒沙门菌临床应用试验失败的原因进行分析。结果 减毒沙门菌一方面可以因其肿瘤靶向定植、兼性厌氧和可携带质粒的特性发挥抑制原发肿瘤生长和减少继发肿瘤转移的作用,另一方面又通过生物工程技术减弱了野生菌株对于宿主的毒性作用。在临床应用方面,因沙门菌过度减毒、人体免疫系统对外来物质的肃清作用以及体内多种蛋白酶的灭活作用影响,减毒沙门菌的抗肿瘤作用远低于预期。结论 减毒沙门菌作为一种细菌介导的抗肿瘤治疗的新兴菌种,一旦其临床应用的问题解决,必将为肿瘤患者精准治疗提供一个新的治疗选择。Objective To provide an overview of the main anti-tumor mechanisms of attenuated Salmonella typhimurium(ST)and explore potential reasons for the limited clinical application of attenuated ST.Methods The literatures related to clinical and basic research on attenuated ST tumor treatment and virulence at home and abroad in recent years were reviewed and the relevant mechanisms of attenuated ST tumor treatment were summarized.And then,analyses were made regarding the failure of clinical application experiments of attenuated ST based on the characteristics of attenuated ST and the human immune microenvironment.Results Attenuated ST could inhibit the growth of primary tumors and reduce the metastasis of secondary tumor due to its effect of tumor-targeting,its property of facultative anaerobic and its characteristic of being able to carry plasmids.On the other hand,the toxicity of wild strains to hosts had been reduced through biotechnology.In terms of clinical application,the anti-tumor effect of attenuated ST was far lower than expected due to excessive detoxification of ST,the elimination effect of foreign substances by the human immune system,and the inactivation effect of various proteases in the body.Conclusion As an emerging bacterial mediated anti-tumor therapy,attenuated ST will provide a new treatment option for precise treatment of cancer patients once its clinical application problems are solved.

关 键 词：减毒沙门菌 抗肿瘤治疗 临床试验 

分 类 号：R730.5[医药卫生—肿瘤]