儿童小肠细菌过度生长与幽门螺杆菌感染的相关性分析  

Correlation analysis between small intestinal bacterial overgrowth and Helicobacter pylori infection in children

作　　者：常煜胤 卢太苓 路明 沈栋林 CHANG Yuyin;LU Tailing;LU Ming;SHEN Donglin(Department of Paediatrics,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221000,China;The second Department of Respiratory Medicine,Xuzhou Children's Hospital,Xuzhou,Jiangsu 221000,China)

机构地区：[1]徐州医科大学附属医院儿科,江苏徐州221000 [2]徐州市儿童医院呼吸内二科,江苏徐州221000

出　　处：《医药前沿》2023年第17期7-9,共3页Journal of Frontiers of Medicine

摘　　要：目的:探讨儿童小肠细菌过度生长(SIBO)与幽门螺杆菌(Hp)感染之间的相关性。方法:选取2020年6月—2022年3月徐州医科大学附属医院儿科住院的78例腹痛伴腹胀患儿,通过碳13呼气试验和快速尿素酶法试验,均为阳性者为Hp阳性组(44例),均为阴性者为Hp阴性组(34例)。通过甲烷氢呼气试验检测两组SIBO的情况。结果:Hp阳性组中有33例(75.00%)为SIBO阳性,Hp阴性组中有7例(20.59%)为SIBO阳性,两组SIBO阳性率比较,差异有统计学意义(χ^(2)=22.728,P<0.05),并且SIOB与Hp呈正相关关系(r=0.475,P<0.05)。结论:SIBO是一种需要高度重视的肠道疾病,儿童SIBO与Hp感染密切相关,故在临床中应该及时发现和治疗Hp感染,并综合考虑各种因素,以制订个性化的治疗方案,提高治疗效果。Objective To explore the correlation between small intestinal bacterial overgrowth(SIBO)and Helicobacter pylori(Hp)infection in children.Methods A total of 78 children with abdominal pain and abdominal distension admitted to the Department of Pediatrics of the Affiliated Hospital of Xuzhou Medical University from June 2020 to March 2022 were selected.By C13 breath test and rapid urease assay,both positive patients were in the HP-positive group(44 cases),and both negative patients were in the HPnegative group(34 cases).Methane and hydrogen breath test were used to detect SIBO in both groups.Results There were 33 cases(75.00%)of SIBO positive in the HP-positive group and 7 cases(20.59%)of SIBO positive in the HP-negative group.The difference in SIBO positive rate between the two groups was statistically significant(χ^(2)=22.728,P<0.05).SIOB was positively correlated with Hp(r=0.475,P<0.05).Conclusions SIBO is an intestinal disease that needs high attention.SIBO in children is closely related to Hp infection.Therefore,Hp infection should be timely detected and treated in clinical practice,and various factors should be comprehensively considered to formulate personalized treatment plan and improve treatment effect.

关 键 词：儿童 小肠细菌过度生长 幽门螺杆菌 甲烷氢呼气试验 相关性分析 

分 类 号：R574.5[医药卫生—消化系统]