有丝分裂结束后细胞代谢通路重启过程探析  

Metabolism rebooting in post-mitotic cells

作　　者：肖党生[1] 鲁海峰[2] 严冬[2] XIAO Dangsheng;LU Haifeng;YAN Dong(Department of Geriatrics,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Disease,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院老年科,浙江杭州310003 [2]浙江大学医学院附属第一医院传染病诊治国家重点实验室,传染病国家临床研究中心,传染病诊治协同创新中心,浙江杭州310003

出　　处：《空军军医大学学报》2023年第8期789-793,共5页Journal of Air Force Medical University

基　　金：国家科技重大专项(民口)课题(2018ZX10101-001)。

摘　　要：能量物质氧化过程和基因表达过程是细胞内的两个核心过程,二者之间相互作用是细胞中各种生命现象的基础。有丝分裂是细胞增殖的基础,有丝分裂结束后,细胞需要对能量代谢过程和基因表达过程进行重启。细胞内存在三种重启代谢过程的模式:葡萄糖主导的代谢通路重启;氨基酸主导的代谢通路重启;脂质主导的代谢通路重启。其中葡萄糖主导的代谢通路重启是顺应能量物质氧化梯度的重启模式,是细胞的最优选择。基因表达过程重启滞后于代谢通路重启。在代谢通路重启过程中,能量物质氧化和基因表达间的正反馈推动细胞分化。细胞内代谢通路重启过程中存在抵抗病毒入侵的时间窗。The processes of energy oxidation and gene expression are two core processes in cells and the interaction between them is the basis of various life phenomena in cells.Mitosis is the basis of cell proliferation.After mitosis,cells need to reboot the processes of energy metabolism and gene expression.There are three models of metabolism rebooting in cells:glucose-dominant rebooting,amino-acids-dominant rebooting,and lipid-dominant rebooting.Among them,glucose-dominant rebooting follows the gradient of energy oxidation,which is the optimal choice for cells.The rebooting of gene expression lags behind metabolism rebooting.In the process of metabolism rebooting,positive feedbacks between energy oxidation and gene expression drive cell differentiation.There is a time window for resistance to virus invasion during the process of metabolism rebooting in cells.

关 键 词：氧化代谢 基因表达 糖酵解 三羧酸循环 有丝分裂 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]