依达拉奉辅助治疗对急性重型颅脑损伤患者神经功能及脑血流动力学指标的影响  

Effects of adjunctive treatment with edaravone on neurological function and cerebral hemodynamic parameters in patients with acute severe craniocerebral injury

作　　者：边媛 王晓娜[1] BIAN Yuan;WANG Xiaona(Department of Pharmacy,Dalian Friendship Hospital,Dalian,Liaoning,160000,China)

机构地区：[1]大连市友谊医院药剂科,辽宁大连160000

出　　处：《当代医学》2023年第9期48-51,共4页Contemporary Medicine

摘　　要：目的探讨依达拉奉辅助治疗对急性重型颅脑损伤患者神经功能及脑血流动力学指标的影响。方法选取2019年2月至2020年6月本院收治的87例急性重型颅脑损伤患者作为研究对象,随机分为对照组(n=43)与观察组(n=44)。对照组给予纳美芬治疗,观察组在对照组基础上加用依达拉奉治疗。比较两组神经功能、神经细胞损伤情况、脑血流动力学指标及颅内压。结果治疗后,两组格拉斯哥昏迷指数(GCS)评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组β-内咖肽、S100β蛋白、神经特异性烯醇化酶(NSE)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组动脉收缩期峰值血流速度(Vs)及平均血流速度(Vm)均快于治疗前,搏动指数(PI)低于治疗前,且观察组Vs、Vm均快于对照组,PI低于对照组,差异有统计学意义(P<0.05);治疗后,两组颅内压水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论依达拉奉辅助治疗急性重型颅脑损伤患者疗效显著,可改善患者脑血流动力学,降低颅内压水平和神经细胞损伤,促进神经功能恢复,值得临床推广应用。Objective To investigate the effects of Edaravone adjuvant therapy on neurological function and cerebral hemodynamics in patients with acute severe craniocerebral injury.Methods A total of 87 patients with acute severe craniocerebral injury admitted to our hospital from February 2019 to June 2020 were selected as study subjects,and they were randomly divided into the control group(n=43)and the observation group(n=44).The control group was treated with nalmefene,and the observation group was treated with Edaravone based on the control group,nerve function,nerve cell injury,cerebral hemodynamics index and intracranial pressure were compared between the two groups.Results After treatment,Glasgow Coma Scale(GCS)score of two groups was higher than before treatment,and observation group was higher than control group,the differences were statistically significant(P<0.05).After treatment,β-endopeptide,S100βprotein and Neuro-specific enolase(NSE)of two groups were lower than before treatment,and observation group was lower than control group,the differences were statistically significant(P<0.05).After treatment,the peak systolic blood flow velocity(Vmax,Vs)and mean blood flow velocity(Vmean,Vm)of the two groups were faster than before treatment,and the Pulse index(PI)was lower than before treatment,and the Vs and Vm of the observation group were faster than the control group,and the PI was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the level of intracranial pressure of two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Conclusion Edaravone is effective in the adjuvant treatment of acute severe craniocerebral injury,which can improve cerebral hemodynamics,reduce intracranial pressure and nerve cell injury,and promote the recovery of nerve function,it is worthy of clinical promotion and application.

关 键 词：急性重型颅脑损伤 纳美芬 依达拉奉 神经功能 脑血流动力学 

分 类 号：R743.33[医药卫生—神经病学与精神病学]