肝巨噬细胞在急性胰腺炎并发肝损伤中的作用及机制研究进展  

Research progress on the role and mechanism of hepatic macrophages in liver injury during acute pancreatitis

作　　者：房智超 李佳敏 王树楷 宋亮 FANG Zhichao;LI Jiamin;WANG Shukai;SONG Liang(Second Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,P.R.China;Basic Medical College,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,P.R.China;Medical Experiment Center,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,P.R.China)

机构地区：[1]陕西中医药大学第二临床医学院,陕西咸阳712046 [2]陕西中医药大学基础医学院,陕西咸阳712046 [3]陕西中医药大学医学科研实验中心,陕西咸阳712046

出　　处：《华西医学》2023年第8期1252-1256,共5页West China Medical Journal

基　　金：陕西省科学技术厅重点研发计划项目(2019SF-294);陕西省“特支计划”区域发展人才项目(2017);陕西省留学人员科技活动择优资助项目(2018046)。

摘　　要：急性胰腺炎(acute pancreatitis,AP)是一种发病急且致死率较高的消化科急腹症,主要发病机制为多种因素诱发的胰腺组织损伤和炎症细胞过度活化。由于其解剖学特点,肝脏是发生AP时最早受到高浓度胰蛋白酶和炎症介质攻击的胰腺外器官。肝巨噬细胞已被证实是AP相关炎性因子的主要来源,针对肝巨噬细胞的靶向干预可能成为阻断AP并发肝损伤/衰竭、促进组织修复、减轻全身症状的关键。该文总结了发生AP时肝巨噬细胞的病理作用以及靶向干预,为解析AP的发病机制及缓解并发肝损伤提供新的思路与方法。Acute pancreatitis(AP)is a gastroenterological emergency with an acute onset and a high mortality rate.The main pathogenesis of AP is pancreatic damage and excessive activation of inflammatory cells induced by multiple factors.Due to anatomical features,the liver is the first extrapancreatic organ to be attacked by high concentrations of trypsin and inflammatory mediators during AP.Hepatic macrophages have been shown to be a major source of AP-related inflammatory factors.Interventions targeting hepatic macrophages may be critical to block liver injury/failure during AP,promote tissue repair,and reduce systemic symptoms.This review summarizes the pathological role of hepatic macrophages in AP and targeted interventions to provide new ideas and approaches to resolve the pathogenesis of AP and alleviate concurrent liver injury.

关 键 词：急性胰腺炎 肝巨噬细胞 免疫调节 炎症因子 

分 类 号：R576[医药卫生—消化系统] R575[医药卫生—内科学]