脉冲低剂量率照射联合累及野调强放疗治疗食管癌的临床疗效  

Clinical efficacy of pulsed low dose rate irradiation combined with involved-field intensity-modulated radiotherapy in the treatment of esophageal cancer

作　　者：姚钧 吴成宝 马高见 YAO Jun;WU Chengbao;MA Gaojian(Department of Radiotherapy,Yancheng Second People's Hospital,Yancheng,Jiangsu,224003,China)

机构地区：[1]盐城市第二人民医院放疗科,江苏盐城224003

出　　处：《当代医学》2023年第5期80-83,共4页Contemporary Medicine

摘　　要：目的探讨脉冲低剂量率照射联合累及野调强放疗治疗食管癌的临床疗效。方法选取2019年1月至2020年3月于盐城市第二人民医院放疗科行放疗的50例初治食管癌患者作为研究对象,按照随机数字表法分为实验组与对照组,每组25例。对照组采用累及野调强放疗方法,实验组采用脉冲低剂量率联合累及野调强放疗方法,比较两组近期疗效和放疗不良反应发生率及局部控制、转移情况。结果实验组近期治疗总有效率为92.0%,对照组为88.0%,两组比较差异无统计学意义。两组≤2级与≥3级骨髓抑制、放射性食管炎发生率比较差异无统计学意义;实验组≤2级放射性肺炎发生率高于对照组,≥3级放射性肺炎发生率低于对照组,差异有统计学意义(P<0.05)。两组局部复发、区域淋巴结转移、远处转移发生率比较差异无统计学意义。结论脉冲低剂量率照射联合累及野调强放疗与累及野调强放疗治疗初治食管癌疗效相当,均可出现骨髓抑制、放射性食管炎情况,但脉冲低剂量率照射联合累及野调强放疗可降低放射性肺炎发生率和严重程度,优势明显。Objective To explore the clinical efficacy of pulsed low dose rate irradiation combined with involved-field intensity-modulated radio-therapy in the treatment of esophageal cancer.Methods 50 patients with esophageal cancer who underwent radiotherapy without operation in the de-partment of Radiotherapy of Yancheng Second People's Hospital from January 2019 to March 2020 were selected as the study subjects,they were di-vided into the experimental group and the control group according to the random number table method,with 25 cases in each group.The control group was treated with involved-field intensity-modulated radiotherapy,and the experimental group was treated with pulse low dose rate combined with involved-field intensity-modulated radiotherapy,the short-term efficacy,incidence of radiotherapy adverse reactions,status of local control and metastasis were compared between the two groups.Results The total short-term treatment effective rate was 92.0%in the experimental group and 88.0%in the control group,and there was no statistical significance between the two groups.There was no significant difference in the incidence of≤2 grade and≥3 grade myelosuppression and radiation esophagitis between the two groups;the incidence of grade≤2 radiation pneumonitis in the ex-perimental group was higher than that in the control group,and the incidence of grade≥3 radiation pneumonitis was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of local recurrence,regional lymph node metastasis and distant metastasis between the two groups.Conclusion The efficacy of pulsed low dose rate irradiation combined with involved-field intensity-modulated radiotherapy in the treatment of primary esophageal cancer is comparable to that of involved-field intensity-modu-lated radiotherapy,both of which can cause myelopathic depression and radiation esophagitis,however,pulsed low dose rate irradiation combined with involved-field intensity-mo

关 键 词：食管肿瘤 调强放疗 累及野 脉冲低剂量率放疗 

分 类 号：R735.1[医药卫生—肿瘤]