腹腔镜辅助胃癌根治术对患者机体细胞免疫及凝血功能和生存率的影响  

Effect of laparoscopic assisted radical gastrectomy on cellular immunity and coagulation function and survival rate of patients with gastric cancer

作　　者：韩大志 姜增岩 凌云志 HAN Dazhi;JIANG Zengyan;LING Yunzhi(Department of General Surgery,Chaoyang Central Hospital,Chaoyang,Liaoning,122000,China)

机构地区：[1]朝阳市中心医院普外科,辽宁朝阳122000

出　　处：《当代医学》2023年第5期91-94,共4页Contemporary Medicine

摘　　要：目的探究腹腔镜辅助胃癌根治术对患者机体细胞免疫及凝血功能和生存率的影响。方法选取2014年1月至2016年1月于本院接受手术治疗的134例胃癌患者作为研究对象,按照随机数字表法划分为观察组与对照组,每组67例。观察组行腹腔镜辅助下的胃癌根治术,对照组行开腹胃癌根治术,比较两组细胞免疫指标、凝血功能指标及生存率。结果术后,两组CD4^(+)、CD4^(+)/CD8^(+)水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05);术后,两组CD8^(+)水平均高于术前(P<0.05),但组间比较差异无统计学意义。术后,两组FIB、PLT水平均明显低于术前,APTT短于术前,但观察组FIB、PLT水平均高于对照组,APTT长于对照组,差异有统计学意义(P<0.05)。两组1、3、5年生存率比较差异无统计学意义。结论腹腔镜辅助胃癌根治术治疗胃癌效果显著,可有效改善患者机体细胞免疫及凝血功能,且术后生存率较高,值得临床推广应用。Objective To explore the effects of laparoscopic assisted radical gastrectomy on cellular immunity,coagulation function and surviv-al rate of patients with gastric cancer.Methods A total of 134 patients with gastric cancer who received surgical treatment in our hospital from Janu-ary 2014 to January 2016 were selected as the research subjects,and they were divided into the observation group and the control group according to random number table method,with 67 cases in each group.The observation group received laparoscopic assisted radical gastrectomy,while the con-trol group received open radical gastrectomy.The cellular immune indexes,coagulation function indexes and survival rate were compared between the two groups.Results After surgery,the levels of CD4^(+)and CD4^(+)/CD8^(+)of the two groups were lower than those before surgery,and the observa-tion group was lower than the control group,the difference was statistically significant(P<0.05);after surgery,the level of CD8^(+)was higher than that before surgery(P<0.05),but there was no statistically significant difference in the level of CD8^(+)between groups after surgery.After surgery,the levels of FIB and PLT of the two groups were significantly lower than those before surgery,and APTT was shorter than before surgery,but the levels of FIB and PLT in the observation group was higher than those in the control group,and APTT was longer than control group,the differences were statistically significant(P<0.05).There was no significant difference in 1,3 and 5-year survival rates between the two groups.Conclusion Laparo-scopic assisted radical gastrectomy has significant effect in the treatment of gastric cancer,which can effectively improve the cellular immunity and coagulation function of patients,and the postoperative survival rate is higher,which is worthy of clinical promotion and application.

关 键 词：腹腔镜辅助胃癌根治术 机体细胞免疫 凝血功能 生存率 

分 类 号：R735.2[医药卫生—肿瘤]