腹腔镜胃癌根治术联合D_(2)淋巴结清扫术前应用纳米活性炭的临床价值  

Clinical value of nano-activated carbon before laparoscopic radical gastrectomy combined with D_(2) lymph node dissection

作　　者：李颖[1] 叶琳[1] 陈志冰[1] LI Ying;YE Lin;CHEN Zhibing(Department of General Surgery,The First People's Hospital of Jiujiang,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市第一人民医院普外科,江西九江332000

出　　处：《当代医学》2023年第8期134-136,共3页Contemporary Medicine

摘　　要：目的探讨腹腔镜胃癌根治术联合D_(2)淋巴结清扫术前应用纳米活性炭的临床价值。方法选取2018年5月至2019年12月在九江市第一人民医院收治的86例胃癌患者作为研究对象,按随机数字表法分为活性炭组与对照组,每组43例。两组均实施腹腔镜胃癌根治术联合D_(2)淋巴结清扫术治疗,活性炭组术前使用纳米活性炭治疗。比较两组淋巴结检获数目、术后淋巴结转移率、肿瘤复发率、死亡率、并发症发生率,分析活性炭组用药不良反应情况。结果活性炭组和对照组分别清扫淋巴结1691枚、1228枚,前者存在黑染淋巴结984枚(58.19%),活性炭组淋巴结总数、淋巴结转移数、微小淋巴结数高于对照组,差异有统计学意义(P<0.05)。活性炭组淋巴结转移率和黑染淋巴结转移率高于对照组,差异有统计学意义(P<0.05)。两组术后肿瘤复发率、死亡率、并发症发生率比较差异无统计学意义。活性炭组无与纳米活性炭相关不良反应发生。结论术前应用纳米活性炭能提高腹腔镜胃癌根治术联合D_(2)淋巴结清扫术中淋巴结清扫数目,降低淋巴结清除难度,安全性较高。Objective To investigate the clinical value of nano-activated carbon before laparoscopic radical gastrectomy combined with D_(2) lymph node dissection.Methods A total of 86 gastric cancer patients admitted to the First People's Hospital of Jiujiang City from May 2018 to December 2019 were selected and divided into activated carbon group and control group according to random number table method,with 43 cases in each group.Both groups were treated with laparoscopic radical gastrectomy combined with D_(2) lymph node dissection,and the activated carbon group was treated with nano-activated carbon before surgery.The number of lymph nodes detected,the rate of postoperative lymph node metastasis,the rate of tumor recurrence,the mortality rate and the incidence of complications were compared between the two groups,and the adverse drug reactions in the activated carbon group were analyzed.Results There were 1691 lymph nodes in activated carbon group and 1228 lymph nodes in control group,respectively.There were 984 black-stained lymph nodes in the former group(58.19%);the number of lymph nodes,the number of lymph nodes metastases and the number of minimal lymph nodes in activated carbon group were higher than those in control group,with statistical significance(P<0.05).The rate of lymph node metastasis and black staining lymph node metastasis in activated carbon group was higher than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the recurrence rate,mortality rate and complication rate between the two groups.No adverse reactions related to nano activated carbon occurred in activated carbon group.Conclusion The preoperative application of nano-activated carbon can increase the number of lymph node dissection in laparoscopic radical gastrectomy combined with D_(2) lymph node dissection,reduce the difficulty of lymph node removal,and has high safety.

关 键 词：胃癌根治术 腹腔镜 D_(2)淋巴结清扫术 纳米活性炭 

分 类 号：R735.2[医药卫生—肿瘤]