标准三联和铋剂四联方案根除幽门螺杆菌感染的回顾性分析  

Retrospective analysis of standard triple therapy and bismuth quadruple therapy for eradication of Helicobacter pylori infection

作　　者：刘卫东[1,2] 旷历琼 孔文洁[1,2] 惠文佳 蒋琦[1,2] 高峰 LIU Weidong;KUANG Liqiong;KONG Wenjie;HUI Wenjia;JIANG Qi;GAO Feng(Department of Gastroenterology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830001,China;Xinjiang Clinical Research Center for Digestive Diseases,Urumqi,Xinjiang,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院消化科,新疆乌鲁木齐830001 [2]新疆消化系统疾病临床医学研究中心,新疆乌鲁木齐830001

出　　处：《当代医学》2023年第2期89-91,共3页Contemporary Medicine

基　　金：新疆维吾尔自治区人民医院院内项目(20190213);新疆维吾尔自治区自然科学基金(2019D01C110)。

摘　　要：目的分析新疆地区单中心标准三联方案和铋剂四联方案治疗幽门螺杆菌(Hp)的根除率。方法选取2017年4月至2019年4月于新疆维吾尔自治区人民医院门诊经碳呼气试验确诊为Hp感染的230例患者作为研究对象,随机分为标准三联组[质子泵抑制剂+2种抗生素]和铋剂四联组(质子泵抑制剂+铋剂+2种抗生素),比较两组治疗依从性和根除率。结果两组治疗依从性比较差异无统计学意义。铋剂四联组意向性(ITT)分析和符合方案(PP)分析根除率分别为81.7%,83.0%,均高于标准三联组的60.0%,61.8%,差异有统计学意义(P<0.05)。结论标准三联方案在新疆地区已无法满足Hp根除率的要求,且铋剂四联方案的根除率还未达到理想水平,需进一步优化铋剂四联方案以提高Hp根除率。Objective Retrospective analysis of standard triple therapy and bismuth quadruple therapy for eradication of Helicobacter pylori fection in Xinjiang by singlecenter researsh.Methods 230 patients with Hp infection diagnosed by carbon breath test in the Outpatient department of the People's Hospital of Xinjiang Uygur Autonomous Region from April 2017 to April 2019 were randomly divided into standard triple group[proton pump inhibitor+2 antibiotics]and bismuth quadruple group(proton pump inhibitor+bismuth+2 antibiotics),the treatment compliance and eradication rate were compared between the two groups.Results There was no significant difference in treatment compliance between the two groups.The eradication rates of intention-to-treat(ITT)analysis and per protocol analysis(PP)analysis in bismuth quadruple group were 81.7%and 83.0%respectively,which were higher than 60.0%and 61.8%in standard triple group,and the differences were statistically significant(P<0.05).Conclusion The standard triple therapy has been unable to meet the requirements of Hp eradication rate in Xinjiang,and the eradication rate of bismuth quadruple therapy has not reached the ideal level,it is necessary to further optimize the bismuth quadruple regimen to improve the Hp eradication rate.

关 键 词：幽门螺杆菌 标准三联 铋剂四联 根除率 

分 类 号：R573[医药卫生—消化系统]