足量丙戊酸钠联合利培酮治疗急性躁狂症的临床疗效  

Clinical efficacy of sufficient sodium valproate combined with risperidone in the treatment of acute mania

作　　者：王聪 杨一娜 崔蕾 WANG Cong;YANG Yina;CUI Lei(Mental Seven Wards,Shenyang Mental Health Center,Shenyang,Liaoning,110168,China)

机构地区：[1]沈阳市精神卫生中心心理七病房,辽宁沈阳110168

出　　处：《当代医学》2023年第3期33-35,共3页Contemporary Medicine

摘　　要：目的探究足量丙戊酸钠联合利培酮治疗急性躁狂症的临床疗效。方法选取2019年12月至2020年12月本院收治的100例急性躁狂症患者作为研究对象,按照随机数字表法分为两组,每组50例。对照组给予利培酮治疗,观察组在对照组基础上联合足量丙戊酸钠治疗,比较两组临床疗效、躁狂评分、认知功能评分、不良反应发生率及炎症因子[白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)]水平。结果观察组治疗总有效率为92.0%,明显高于对照组的74.0%,差异有统计学意义(P<0.05)。治疗前,两组躁狂评分、认知功能评分比较差异无统计学意义;治疗后,两组躁狂评分均低于治疗前,认知功能评分均高于治疗前,且观察组躁狂评分均低于对照组,认知功能评分均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。治疗前,两组IL-4、TNF-α水平差异无统计学意义;治疗后,观察组IL-4、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论足量丙戊酸钠联合利培酮治疗急性躁狂症效果确切,可有效缓解患者躁狂症状,改善认知功能,不良反应发生率低,利于促进患者尽快康复,值得临床推广应用。Objective To explore the clinical efficacy of sufficient sodium valproate combined with risperidone in the treatment of acute mania.Methods 100 patients with acute mania admitted to our hospital from December 2019 to December 2020 were selected as the research subjects,and they were divided into two groups according to random number table method,with 50 cases in each group.The control group was treated with risperidone,and the observation group was treated with sufficient sodium valproate on the basis of the control group,the clinical efficacy,manic score,cognitive function score,incidence of adverse reactions,the levels of inflammatory factors(interleukin-4[IL-4],tumor necrosis factor-α[TNF-α])were compared between the two groups.Results The total effective rate in the observation group was 92.0%,which was significantly higher than 74.0%in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in manic scores and cognitive function scores between the two groups;after treatment,the manic scores of two groups were lower than before treatment,and the cognitive function scores were higher than before treatment,and the manic scores in the observation group were lower than the control group,and the cognitive function scores were higher than the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Before treatment,there was no significant difference in the levels of IL-4 and TNF-αbetween the two groups.After treatment,the levels of IL-4 and TNF-αin the observation group were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Conclusion Sufficient sodium valproate combined with risperidone in the treatment of acute mania is effective,can effectively relieve the symptoms of mania,improve cognitive function,low incidence of adverse reactions,

关 键 词：急性躁狂症 丙戊酸钠 利培酮 足量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]