Two-dimensional molecular condensation in cell signaling and mechanosensing  

作　　者：Xiangfu Guo Kexin Zhu Xinlu Zhu Wenting Zhao Yansong Miao 

机构地区：[1]School of Chemistry,Chemical Engineering and Biotechnology,Nanyang Technological University,Singapore 637457,Singapore [2]School of Biological Sciences,Nanyang Technological University,Singapore 637551,Singapore [3]Institute for Digital Molecular Analytics and Science,Nanyang Technological University,Singapore 636921,Singapore

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第7期1064-1074,共11页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the Human Frontier Science Program Foundation(No.RGY0088/2021 to W.Z.);the Start-up Grant from Nanyang Technological University to W.Z.,Ministry of Education,Singapore(Nos.RG112/20,RG95/21,RG93/22,MOE-MOET32020-0001 to W.Z.);National Research Foundation,Singapore(No.NRF2019-NRF-ISF003-3292 to W.Z.);Singapore MOE Tier 2(Nos.MOE-T2EP30121-0015 and MOET2EP30122-0021 to Y.M.);MOE Tier 3(No.MOE2019-T3-1-012 to Y.M.);National Research Foundation Singapore under its Open Fund-Individual Research Grant(No.MOH-000955 to Y.M.);National Research Foundation-Quantum Sensors for Health and Life Sciences(No.NRF2021-QEP2-03-P10 to Y.M.).

摘　　要：Membraneless organelles(MLO)regulate diverse biological processes in a spatiotemporally controlled manner spanning from inside to outside of the cells.The plasma membrane(PM)at the cell surface serves as a central platform for forming multi-component signaling hubs that sense mechanical and chemical cues during physiological and pathological conditions.During signal transduction,the assembly and formation of membrane-bound MLO are dynamically tunable depending on the physicochemical properties of the surrounding environment and partitioning biomolecules.Biomechanical properties of MLO-associated membrane structures can control the microenvironment for biomolecular interactions and assembly.Lipid-protein complex interactions determine the catalytic region’s assembly pattern and assembly rate and,thereby,the amplitude of activities.In this review,we will focus on how cell surface microenvironments,including membrane curvature,surface topology and tension,lipid-phase separation,and adhesion force,guide the assembly of PM-associated MLO for cell signal transductions.

关 键 词：two-dimensional molecular condensation membrane-bound MLO signal transduction MECHANOSENSING 

分 类 号：Q6[生物学—生物物理学]