MECHANOSENSING

作品数：15被引量：28H指数：3
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相关领域：医药卫生更多>>
相关作者：李靖杨春更多>>
相关机构：清华大学更多>>
相关期刊：《Journal of Biomedical Science and Engineering》《Cancer Communications》《Acta Biochimica et Biophysica Sinica》《Acta Mechanica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划更多>>
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Mechanobiology of Type 1 hypersensitivity:Elucidating the impacts of mechanical forces in allergic reactions被引量：1
《Mechanobiology in Medicine》2024年第1期48-56,共9页Henry Sutanto 
Type 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen exposure,leading to rapid release of inflammatory mediators.Meanwhile,mechanobiology explores how physical forces influence cellula...
关键词：Type 1 hypersensitivity MECHANOBIOLOGY MECHANOSENSING MECHANOTRANSDUCTION ALLERGY 
Biomechanical control of lymphatic vessel physiology and functions被引量：3
《Cellular & Molecular Immunology》2023年第9期1051-1062,共12页Veronique Angeli Hwee Ying Lim 
This work was supported by NUHS internal funding and the Ministry of Education(Project 594 ID:MOE2019-T2-1-136)to VA and the National Medical Research Council(Y-IRG grant)to HYL。
The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis,immunosurveillance,lipid met...
关键词：lymphatic vessel biomechanical force MECHANOSENSING MECHANOTRANSDUCTION human diseases 
Two-dimensional molecular condensation in cell signaling and mechanosensing
《Acta Biochimica et Biophysica Sinica》2023年第7期1064-1074,共11页Xiangfu Guo Kexin Zhu Xinlu Zhu Wenting Zhao Yansong Miao 
supported by the grants from the Human Frontier Science Program Foundation(No.RGY0088/2021 to W.Z.);the Start-up Grant from Nanyang Technological University to W.Z.,Ministry of Education,Singapore(Nos.RG112/20,RG95/21,RG93/22,MOE-MOET32020-0001 to W.Z.);National Research Foundation,Singapore(No.NRF2019-NRF-ISF003-3292 to W.Z.);Singapore MOE Tier 2(Nos.MOE-T2EP30121-0015 and MOET2EP30122-0021 to Y.M.);MOE Tier 3(No.MOE2019-T3-1-012 to Y.M.);National Research Foundation Singapore under its Open Fund-Individual Research Grant(No.MOH-000955 to Y.M.);National Research Foundation-Quantum Sensors for Health and Life Sciences(No.NRF2021-QEP2-03-P10 to Y.M.).
Membraneless organelles(MLO)regulate diverse biological processes in a spatiotemporally controlled manner spanning from inside to outside of the cells.The plasma membrane(PM)at the cell surface serves as a central pla...
关键词：two-dimensional molecular condensation membrane-bound MLO signal transduction MECHANOSENSING 
Tunable nano-engineered anisotropic surface for enhanced mechanotransduction and soft-tissue integration
《Nano Research》2023年第5期7293-7303,共11页Pingping Han Tianqi Guo Anjana Jayasree Guillermo A.Gomez Karan Gulati Sašo Ivanovski 
T.G.and A.J.are supported by the University of Queensland Graduate School Scholarships(UQGSS).K.G.is supported by the National Health and Medical Research Council(NHMRC)Early Career Fellowship(No.APP1140699).
Electrochemically engineered titania(TiO_(2))nanopores enable tailored cellular function;however,the cellular mechanosensing mechanisms dictating the cell response and soft tissue integration are yet to be elucidated....
关键词：titanium NANOPORES NANOTOPOGRAPHY fibroblast mechanosensing MECHANOTRANSDUCTION ligament differentiation 
Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration
《Journal of Molecular Cell Biology》2022年第11期1-8,共8页Daijiao Tang Yue Zhang Jie Mei Jing Zhao Chenglin Miao Yaming Jiu 
supported by the National Key Research and Development Program of China(2022YFC2303502 and 2021YFC2300204);the National Natural Science Foundation of China(32222022,92054104,and 31970660);CAS-VPST Silk Road Science Fund(GJHZ2021138);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02).
Introduction Cell mechanosensing is the process that cell senses extracellular mechanical cues through mechanosensors and transduces them to downstream signaling pathways to alter cell mechanics and behaviors,which is...
关键词：MEC INVASION 
A novel electrospinning method for self-assembled tree-like fibrous scaffolds:Microenvironment-associated regulation of MSC behavior and bone regeneration被引量：3
《Journal of Materials Science & Technology》2022年第20期52-70,共19页Jeong In Kim Ju Yeon Kim Sung-Ho Kook Jeong-Chae Lee 
the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science,Information and Communications Technology and Future Planning(Nos.2019R1A2C2084453,2021R1A2C2006032,and 2021R1C1C2011469),Republic of Korea。
Numerous studies highlight advantages of electrospun scaffolds in bone tissue engineering,in which cellular behavior is tightly affected by fiber topographical cues of scaffolds.However,the classic electrospinning set...
关键词：ELECTROSPINNING Advanced biomimetic scaffolds Stem cell behavior MECHANOSENSING Bone tissue engineering 
Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis被引量：9
《Cancer Communications》2022年第5期374-400,共27页Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu 
National Natural Science Foundation of China,Grant/Award Numbers:U19A2006,12132004,11972111,31900940,32071304,32171309,32171395;Sichuan Science and Technology Program,Grant/Award Number:21YJ0130;Joint Funds of Center for Engineering Medicine,Grant/Award Numbers:ZYGX2021YGLH017,ZYGX2021YGLH010,ZYGX2021YGLH023。
Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fra...
关键词：tumor microenvironment mechanical model MECHANOSENSING MECHANOTRANSDUCTION cytoskeleton remodelin 
Construction of skin-electrode mechanosensing structure for wearable and epidermal electronic sensor被引量：2
《Science Bulletin》2022年第6期569-571,共3页Wenke Yang Hu Liu Chuntai Liu Changyu Shen 
supported by the National Natural Science Foundation of China(51803191,12072325);the National Key R&D Program of China(2019YFA0706802);the 111 Project(D18023);Key Scientific and Technological Project of Henan Province(202102210038)。
Inspired by the excellent sensory function of skin,many efforts have been devoted to developing advanced wearable and epidermal electronic sensors,aiming to realize the accurate and rapid detection of physiological si...
关键词：电子传感器 可穿戴 电极界面 
Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling被引量：1
《Science China(Life Sciences)》2019年第10期1368-1374,共7页Jian Li Yun Zou Zhifang Li Yaming Jiu 
supported by Collaborative Research Grant (KLMVI-OP-201904) of CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences;the starting grant of Institut Pasteur of Shanghai (1185170000), Chinese Academy of Sciences
Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments,microtubules, and intermediate filaments(IFs), which is a hitherto poorly investigated area o...
关键词：intermediate FILAMENTS ACTIN CYTOSKELETAL interaction CELL migration SIGNALING pathway CELL MECHANOSENSING 
Mechanosensing via Immunereceptors
《医用生物力学》2019年第A01期9-9,共1页Cheng Zhu Wei Chen Jizhong Lou William Rittase Kaitao Li 
The immune response is orchestrated by a variety of immune cells,the function of which then is determined by the collective signals from different immunoreceptors.Recent studies have highlighted the presence of mechan...
关键词：MECHANOSENSING Immunereceptors 
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