胃食管反流病与特发性肺纤维化关系的研究进展  

Research progress on the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis

作　　者：吕昆明 王沙沙[2] 万军[1] 令狐恩强[2] Kunming Lv;Shasha Wang;Jun Wan;Enqiang Linghu(Department of Gastroenterology,Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Department of Gastroenterology and Hepatology,First Medical Center of The Chinese PLA General Hospital,Beijing,100853,China)

机构地区：[1]解放军总医院第二医学中心消化内科,国家老年医学研究中心,北京100853 [2]解放军总医院第一医学中心消化内科医学部,北京100853

出　　处：《中华胃肠内镜电子杂志》2023年第2期121-124,共4页Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)

基　　金：国家老年疾病临床医学研究中心开放课题(NCRCGPLAGH-2022003)。

摘　　要：胃食管反流病(GERD)的临床表现除了反酸、烧心外,还可引起一系列食管外表现,其中,呼吸系统相关疾病发生率高。特发性肺纤维化(IPF)是一种以纤维化、炎症和肺结构破坏为特征的慢性间质性肺疾病,在其发病过程中,胃食管反流所致的长期慢性微量误吸具有重要的作用。本文将从GERD与特发性肺纤维化的相关性、抑酸及抗反流治疗在特发性肺纤维化治疗过程中的作用做一综述。In addition to acid reflux and heartburn,the clinical manifestations of gastroesophageal reflux disease(GERD)can also include a series of extrA-esophageal complications,among which the incidence of respiratory system related diseases is high.Idiopathic pulmonary fibrosis(IPF)is a chronic interstitial lung disease characterized by fibrosis,inflammation and lung structure destruction.Long-term chronic microaspiration caused by gastroesophageal reflux plays an important role in the pathophysiological process of idiopathic pulmonary fibrosis.This article will review the relationship between gastroesophageal reflux disease and idiopathic pulmonary fibrosis,the role of acid suppression and anti-reflux therapy in the treatment of idiopathic pulmonary fibrosis.

关 键 词：胃食管反流 特发性肺纤维化 抑酸治疗 抗反流手术 

分 类 号：R571[医药卫生—消化系统] R-332[医药卫生—内科学]