UV固化制备聚(L-乳酸)/壳聚糖薄膜及其热学、力学及抑菌性能研究  

Preparation of poly(L⁃lactic acid)/chitosan films through UV curing and their thermal,mechanical and antibacterial properties

作　　者：杜乐 胡娅洁 胡健 孙滔 云雪艳 董同力嘎 DU Le;HU Yajie;HU Jian;SUN Tao;YUN Xueyan;DONG Tungalag(College of Food Science and Engineering,Inner Mongolia Agriculture University,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学食品科学与工程学院,呼和浩特010018

出　　处：《中国塑料》2023年第8期38-44,共7页China Plastics

基　　金：国家自然科学基金项目(21965026);内蒙古自治区科技计划项目(2021G337);内蒙古自治区青年科技人才发展项目(创新团队)(NMGIRT2310)。

摘　　要：首先合成低分子量聚(L-乳酸)(PLLA)和聚(衣康酸-co-丁二醇)(PBI),然后将其共混进行缩聚反应得到高分子量聚(L-乳酸-co-衣康酸-co-丁二醇)共聚物(PLBI);其次将壳聚糖(Cs)与甲基丙烯缩水甘油酯(GMA)进行接枝反应,得到带有双键基团的壳聚糖共聚物(Cs-g-GMA);最后将Cs-g-GMA涂覆PLBI薄膜通过UV照射进行层合得到界面由共价键结合的PLBI/Cs-g-GMA抑菌薄膜。核磁分析结果证明PLBI和Cs-g-GMA共聚物成功合成;PLBI/Cs-gGMA薄膜的红外分析结果表明PLBI薄膜与Cs-g-GMA成功接枝;力学性能测试结果表明PLBI薄膜力学性能显著提升,断裂伸长率可达214.3%;PLBI/Cs-g-GMA薄膜因支链化严重导致出现力学性能下降的趋势;亲水性测试结果显示PLBI/Cs-g-GMA薄膜亲水性增强、细胞相容性较好;PLBI/Cs-g-GMA薄膜对大肠杆菌表现出良好的抑菌效果,抑菌率最高可达83.4%。A low molecular⁃weight poly(L⁃lactic acid)(PLLA)and poly(icconic acid⁃co⁃butanediol)(PBI)were first synthesized,and the resulting two copolymers were mixed to obtain high molecular weight poly(L⁃lactic acid co⁃icconic acid⁃co⁃butanediol)(PLBI)through a polycondensation reaction.Then,chitosan(Cs)was grafted with glycidyl methac⁃rylate(GMA)to obtain a GMA⁃grafted chitosan copolymer(Cs⁃g⁃GMA)with double bond groups.Finally,the result⁃ing Cs⁃g⁃GMA and PLBI films were laminated through UV curing to obtain a PLBI/Cs⁃g⁃GMA bacteriostatic film with covalent bonds at the interface.NMR analysis indicated that PLBI and Cs⁃g⁃GMA copolymers were successfully pre⁃pared.The infrared spectroscopic analysis of the PLBI/Cs⁃g⁃GMA film demonstrated that Cs⁃g⁃GMA was successfully grated into the PLBI film.Mechanical test results indicated that the mechanical properties of PLBI film were significantly improved,and its elongation at break reached 214.3%.Hydrophilic test results indicated that the hydrophilicity of the PLBI/Cs⁃g⁃GMA film was enhanced together with good cytocompatibility.The PLBI/Cs⁃g⁃GMA film exhibited a good antibacterial effect on escherichia coli with an antibacterial rate as high as 83.4%.

关 键 词：聚乳酸 壳聚糖 紫外光接枝 力学性能 抑菌 

分 类 号：TQ321[化学工程—合成树脂塑料工业]