叉头框蛋白P3阳性调节性T细胞和程序性死亡受体1/程序性死亡受体配体1通路在早期胃癌中的表达及相关性分析  

Expression and correlation analysis of forkhead box protein P3 positive regulatory T cells and programmed death-1/programmed death-ligand 1 pathway in early gastric cancer

作　　者：秦玉翠 夏芸 QIN Yucui;XIA Yun(Health Management Centre,Nanjing Pukou District Hospital of Traditional Chinese Medicine,Jiangsu Province,Nanjing 211800,China;Department of Spleen and Stomach,Nanjing Pukou District Hospital of Traditional Chinese Medicine,Jiangsu Province,Nanjing 211800,China)

机构地区：[1]南京市浦口区中医院健康管理中心,江苏南京211800 [2]南京市浦口区中医院脾胃科,江苏南京211800

出　　处：《中国医药导报》2023年第23期34-37,共4页China Medical Herald

基　　金：江苏省南京市卫生科技发展专项项目(YKK20210)。

摘　　要：目的探讨叉头框蛋白P3阳性调节性T细胞(FOXP3+Tregs)与程序性死亡受体1(PD-1)/程序性死亡受体配体1(PD-L1)通路在早期胃癌患者中的表达及相关性。方法收集2020年10月至2022年6月南京市浦口区中医院收治的早期胃癌患者(早期胃癌组)和慢性胃炎患者的胃黏膜组织(对照组)各10例,采用组织免疫荧光法分别检测早期胃癌组和对照组的胃黏膜组织中FOXP3+Tregs及PD-1/PD-L1通路的表达情况,分析早期胃癌组织中两者表达的相关性。结果早期胃癌组FOXP3+Tregs、PD-1、PD-L1表达水平均高于对照组,差异有统计学意义(P<0.05或P<0.01)。早期胃癌组胃黏膜组织中FOXP3+Tregs分别与PD-1、PD-L1表达水平呈正相关(r>0,P<0.01)。结论早期胃癌组织中存在FOXP3+Tregs和PD-1/PD-L1通路的共同表达,提示联合二者可为临床早期胃癌的判定提供重要参考。Objective To investigate the expression and correlation of forkhead box protein P3 positive regulatory T cells(FOXP3+Tregs)and programmed death-1(PD-1)/programmed death-ligand 1(PD-L1)pathway in patients with early gastric cancer.Methods Gastric mucosa tissues of ten patients with early gastric cancer(early gastric cancer group)and ten patients with chronic gastritis(control group)admitted to Nanjing Pukou District Hospital of Traditional Chinese Medicine from October 2020 to June 2022 were collected.Tissue immunofluorescence was used to detect the expression of FOXP3+Tregs and PD-1/PD-L1 pathway in the gastric mucosa of the early gastric cancer group and the control group,and the correlation between the expression of them in early gastric cancer tissues was analyzed.Results The expression levels of FOXP3+Tregs,PD-1,and PD-L1 in the early gastric cancer group were higher than those in the control group,and the differences were statistically significant(P<0.05 or P<0.01).FOXP3+Tregs were positively correlated with PD-1 and PD-L1 expression in gastric mucosa of early gastric cancer group(r>0,P<0.01).Conclusion FOXP3+Tregs and PD-1/PD-L1 pathway are co-expressed in early gastric cancer tissues,suggesting that the combination of them can provide important reference for the determination of clinical early gastric cancer.

关 键 词：早期胃癌 叉头框蛋白P3 调节性T细胞 程序性死亡受体1 程序性死亡受体配体1 

分 类 号：R735.2[医药卫生—肿瘤]