抽动障碍伴或不伴注意缺陷多动障碍儿童N2、P3a的事件相关电位研究  

Event-related potentials study of N2 and P3a in children with tic disorders with or without attention deficit hyperactivity disorder

作　　者：任永颖 刘子奇 张樊 王小月 杨文民[2] 孙静[2] 张建昭[2] 王昕[2] 杨健 REN Yongying;LIU Ziqi;ZHANG Fan;WANG Xiaoyue;YANG Wenmin;SUN Jing;ZHANG Jianzhao;WANG Xin;YANG Jian(Department of Neurology,Capital Institute of Pediatrics-Peking University Teaching Hospital,Beijing 100020,China;Department of Neurology,Children’s Hospital Capital Institute of Pediatrics,Beijing 100020,China;Department of Neurology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学首都儿科研究所教学医院神经内科,北京100020 [2]首都儿科研究所附属儿童医院神经内科,北京100020 [3]北京大学第一医院神经内科,北京100034

出　　处：《中国医药导报》2023年第23期90-93,98,共5页China Medical Herald

基　　金：国家中医药管理局儿科抽动疾病循证能力提升项目(2019XZZX-EK001);首都儿科研究所横向课题(22-31)。

摘　　要：目的探讨共患注意缺陷多动障碍(ADHD)对于抽动障碍(TD)患儿反应抑制及注意功能的影响,为TD患儿的认知功能研究提供新的参考。方法选取2022年3月至9月于首都儿科研究所附属儿童医院神经内科及保健科门诊就诊的儿童共95例,分为单纯TD组(47例)、TD共患ADHD组(19例)、正常对照组(29例),对所有儿童进行事件相关电位N2、P3a的检测。利用SPSS 26.0统计学软件对三组ERP成分N2、P3a波幅和潜伏期进行分析。结果TD+ADHD组C3点的N2波幅显著低于正常对照组,差异有统计学意义(P<0.05)。TD+ADHD组Pz点的P3a波幅低于正常对照组,差异有统计学意义(P<0.05)。慢性TD患儿、慢性TD+ADHD患儿Oz点的P3a波幅低于正常对照组,差异有统计学意义(P<0.05)。结论共患ADHD会导致TD患儿反应抑制功能损害,慢性TD患儿存在注意认知功能受损。Objective To explore the effects of comorbid attention deficit hyperactivity disorder(ADHD)on response inhibition and attention function in children with tic disorders(TD),and to provide a new reference for the study of cognitive function in children with TD.Methods A total of 95 children were selected from March to September 2022 from the outpatient Department of Neurology and the Department of Health Care in the Children’s Hospital Capital Institute of Pediatrics.They were divided into simple TD group(47 cases),TD comorbid with ADHD group(19 cases),and normal group(29 cases).All children were tested for event-related potentials N2 and P3a.The amplitude and latency of ERP components N2 and P3a were analyzed by statistics software SPSS 26.0.Results The amplitude of N2 at C3 point in TD+ADHD group was lower than that in control group,and the difference was statistically significant(P<0.05).The P3a amplitude at Pz point in TD+ADHD group was lower than that in control group,and the difference was statistically significant(P<0.05).The P3a amplitude at Oz point in chronic TD group and chronic TD+ADHD group was significantly lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Comorbid ADHD can lead to the impairment of response inhibition function in children with TD,and impaired attentional cognitive function exists in children with chronic TD.

关 键 词：抽动障碍 反应抑制 注意认知 事件相关电位 儿童 

分 类 号：R748[医药卫生—神经病学与精神病学]