淋巴细胞功能相关抗原1/细胞间黏附分子在眼干燥症中的发病机制及免疫抑制相关药物的研究进展  

Research progress in pathogenesis of lymphocyte function-associated antigen 1/intercellular adhesion molecule in ophthalmoxerosis and immun-osuppressive drugs

作　　者：沙咏怡 孔雪晴 项敏泓[1] SHA Yongyi;KONG Xueqing;XIANG Minhong(Department of Ophthalmology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)

机构地区：[1]上海中医药大学附属普陀医院眼科,上海200062

出　　处：《中国医药导报》2023年第24期36-39,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82074495);上海市普陀区中心医院临床匠才计划项目(2022-RCJC-06)。

摘　　要：淋巴细胞功能相关抗原1(LFA-1)与细胞间黏附分子(ICAM-1)是同源配体,LFA-1/ICAM-1的相互作用是免疫细胞增殖和浸润的关键。眼干燥症的发病有传入臂、传出臂两条通路。传入臂即抗原提呈细胞受眼表刺激后转移至淋巴结;传出臂即激活的淋巴细胞从淋巴结转移至眼表。LFA-1/ICAM-1在传入臂与传出臂上都发挥重要作用,对免疫稳态破坏相关疾病的诊断和治疗有重要意义。从免疫病理角度治疗眼干燥症的药物Lifitegrast、皮质类固醇与环孢素A在临床已见成效。本文就LFA-1/ICAM-1在眼干燥症中的发病机制及免疫抑制相关药物的研究进展做一综述。Lymphocyte function-associated antigen 1(LFA-1)and intercellular adhesion molecule(ICAM-1)are homologous ligands,the interaction of LFA-1/ICAM-1 is crucial for the proliferation and infiltration of immune cells.The pathogenesis of ophthalmoxerosis has afferent arm and efferent arm two pathways.The afferent arm refers to the transfer of antigen presenting cells to lymph nodes after being stimulated by the ocular surface;the efferent arm refers to the transfer of activated lymphocytes from lymph nodes to the ocular surface.LFA-1/ICAM-1 plays an important role in both the afferent and efferent arms,and is important for the diagnosis and treatment of diseases related to immune homeostasis destruction.The drugs of Lifitegrast,corticosteroids,and cyclosporine A used to ophthalmoxerosis from the perspective of immunopathology have achieved clinical results.This article reviews the pathogenesis of LFA-1/ICAM-1 in ophthalmoxerosisand the research progress of immunosuppressive drugs.

关 键 词：眼干燥症 淋巴细胞功能相关抗原1 细胞间黏附分子 淋巴细胞 眼表免疫反应 

分 类 号：R77[医药卫生—眼科]