特殊临床表现多系统免疫相关不良事件1例  

Multiple immune related adverse events with special clinical manifestations:A case report

作　　者：李阳[1] 默峰 辛志飞 王倩 邓新娜[1] Li Yang;Mo Feng;Xin Zhifei;Wang Qian;Deng Xinna(Fourth Department of Oncology,Hebei General Hospital,Shijiazhuang 050051,China;Third Department of Neurosurgery,Hebei General Hospital,Shijiazhuang 050051,China;Department of Thoracic Surgery,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院肿瘤四科,河北石家庄050051 [2]河北省人民医院神经外三科,河北石家庄050051 [3]河北省人民医院胸外科,河北石家庄050051

出　　处：《临床荟萃》2023年第7期633-637,共5页Clinical Focus

摘　　要：目的报道特殊临床表现多系统免疫相关不良事件个案,探讨本例免疫相关性不良反应发生的机制及危险因素,提高对该病的认识。方法分析本例患者的临床病例资料及诊治过程,并复习相关文献进行讨论。结果本例特殊临床表现多系统免疫相关不良事件患者,免疫相关性肺炎为G3,免疫相关性肝炎为G2,免疫相关性内分泌毒性G2。症状好转后仍死亡。结论特殊临床表现多系统免疫相关不良事件临床罕见,发病机制、危险因素、治疗方法仍存争议,虽发生率低,但预后差,值得进一步研究。Objective To report a case of special clinical manifestations of multi system immune related adverse events,discuss the mechanism and risk factors of immune related adverse reactions in this case,and improve the understanding of the disease.Methods The clinical data,diagnosis and treatment process of this patient were analyzed,and the related literature was reviewed for discussion.Results In this patient with special clinical manifestations of multiple immune related adverse events,immune related pneumonia was G3,immune related hepatitis was G2,and immune related endocrine toxicity was G2.He still died after the symptoms improved.Conclusion The special clinical manifestations of multi system immune related adverse events are rare,and the pathogenesis and risk factors of treatment are still controversial.Although the incidence is low,the prognosis is poor,which is worth further study.

关 键 词：PD-1抑制剂 卡瑞利珠单抗 特殊临床表现 免疫相关性不良事件 

分 类 号：R736.1[医药卫生—肿瘤]