血清转化生长因子-β1、血管内皮生长因子水平与食管癌手术患者预后的关系  

Relationship between serum transforming growth factor-β1,vascular endothelial growth factor and prognosis of patients undergoing esophageal cancer surgery

作　　者：杨忠强 杨海湾 YANG Zhongqiang;YANG Haiwan(Department of Thoracic Surgery,Anyang People’sHospital,Anyang 455000,He’nan,China)

机构地区：[1]安阳市人民医院胸外科,河南安阳455000

出　　处：《癌症进展》2023年第13期1463-1466,共4页Oncology Progress

摘　　要：目的 探讨血清转化生长因子-β1(TGF-β1)、血管内皮生长因子(VEGF)水平与食管癌手术患者预后的关系。方法 选取121例食管癌患者,均接受胸腹腔镜食管癌根治术治疗,随访1年,根据预后情况将患者分为带瘤生存组和无瘤生存组。比较两组患者的临床特征、血清学指标[鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)、TGF-β1、VEGF]。采用多因素Cox回归模型分析食管癌手术患者预后的影响因素,绘制受试者工作特征(ROC)曲线并计算曲线下面积(AUC),分析术前血清TGF-β1、VEGF单独及联合检测对食管癌手术患者预后的预测价值。结果 随访1年,121例食管癌患者的带瘤生存率为38.02%(46/121)。带瘤生存组患者的TNM分期明显高于无瘤生存组,差异有统计学意义(P﹤0.01)。带瘤生存组患者术前血清SCC-Ag、CEA、TGF-β1、VEGF水平均明显高于无瘤生存组,差异均有统计学意义(P﹤0.01)。术前血清SCC-Ag、CEA、TGF-β1、VEGF水平均是食管癌手术患者预后的独立影响因素(P﹤0.05)。ROC曲线显示,术前血清TGF-β1、VEGF单独及联合检测对食管癌手术患者预后均具有中等预测价值,联合检测的AUC为0.829,高于单独检测的0.734和0.765。结论 食管癌手术患者预后可能与术前血清TGF-β1、VEGF水平有关,临床可针对TGF-β1、VEGF采取靶向治疗,从而降低食管癌患者术后复发风险,改善患者预后。Objective To investigate the relationship between serum transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF)and prognosis of patients undergoing esophageal cancer surgery.Method A total of 121 patients with esophageal cancer were selected,and all patients treated with thoracoscopic and laparoscopic radical esophagectomy.The patients were followed up for 1 year and divided into tumor-bearing survival group and tumor-free survival group according to the prognosis.The clinical characteristics and serological indexes[squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA),cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),TGF-β1 and VEGF]were compared between the two groups.Multivariate Cox regression model was used to analyze the prognostic factors of patients undergoing esophageal cancer surgery.The receiver operating characteristic(ROC)curve was plotted and the area under the curve(AUC)was calculated,and the value of single or combined detection of preoperative serum TGF-β1 and VEGF in predicating prognosis of patients undergoing esophageal cancer surgery were analyzed.Result The tumor-bearing survival rate of 121 patients with esophageal cancer was 38.02%(46/121)after 1 year of follow up.The TNM stage of the tumor-bearing survival group was higher than that of the tumor-free survival group(P<0.01).The preoperative serum SCC-Ag,CEA,TGF-β1 and VEGF levels in the tumor-bearing survival group were significantly higher than those in the tumor-free survival group(P<0.01).Preoperative serum SCC-Ag,CEA,TGF-β1 and VEGF levels were independent prognostic factors for patients undergoing esophageal cancer surgery(P<0.05).ROC curve showed that single and combined detection of preoperative serum TGF-β1 and VEGF had moderate predictive value for the prognosis of patients undergoing esophageal cancer surgery,the AUC of combined detection was 0.829,which was higher than 0.734 and 0.765 of single detection.Conclusion The prognosis of patients undergoing esophageal cancer surgery may be

关 键 词：食管癌 胸腹腔镜食管癌根治术 转化生长因子-Β1 血管内皮生长因子 

分 类 号：R735.1[医药卫生—肿瘤]