经皮射频消融治疗进展期非小细胞肺癌的效果及影响因素分析  

Effect of percutaneous radiofrequency ablation on advanced non-small cell lung cancer and logistic regression analysis of related factors

作　　者：黄乐 李公星 HUANG Le;LI Gongxing(Department of Respiratory and Critical Care Medicine,Shangqiu Fourth People's Hospital,Shangqiu,Henan 476000,China)

机构地区：[1]河南省商丘市第四人民医院呼吸与危重症医学科,476000

出　　处：《淮海医药》2023年第4期337-340,共4页Journal of Huaihai Medicine

摘　　要：目的:探讨经皮射频消融(PREA)治疗进展期非小细胞肺癌(NSCLC)的效果及影响因素。方法:选取某院2018年3月—2022年2月收治的NSCLC患者146例作为研究对象,收集患者一般资料(性别、年龄、病理类型、BMI、肿瘤分期、既往治疗方式、吸烟史、淋巴结是否阳性、病灶直径、有无脑转移、有无骨转移、美国东部肿瘤协作组织(ECOG)评分、肿瘤类型),经PREA治疗后依据实体肿瘤疗效评估标准评估治疗效果,根据治疗效果分为无效组和有效组。采用单因素和多因素Logistic回归分析影响治疗效果的危险因素。结果:经PREA治疗后,90例患者达到有效标准,有效率为61.64%。2组间年龄、既往治疗方式、病灶直径、是否发生骨转移及肿瘤类型比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄(OR=0.351,95%CI=0.145~0.852)、既往治疗方式(OR=3.253,95%CI=1.463~7.234)、病灶直径(OR=0.437,95%CI=0.235~0.813)、肿瘤类型(OR=2.970,95%CI=1.367~6.451)是影响NSCLC患者PREA治疗效果的独立因素。结论:年龄、病灶直径、既往治疗方式、肿瘤类型是影响PREA治疗NSCLC患者效果的独立因素,临床可根据患者具体病情选择合适的治疗方案,以控制肿瘤进展、延长生存周期。Objective:To investigate the fficacy of percutaneous radiofrequency ablation(PREA)in the treatment of non-small cell lung cancer(NSCLC)and its influencing factors.Methods:146 patients with NSCLC admitted to a hospital from March 2018 to February 2022 were selected as the study objects.Clinical data(gender,age,pathological type,BMI,tumor stage,previous treatment modality,smoking history,positive lymph nodes,lesion diameter,brain metastasis,bone metastasis,ECOG score,and tumor type)were collected.After treatment with PREA,the treatment effectiveness rate(response rate,RR)was counted,and based upon the RR,the patients were divided into an effective group and an ineffctive group.The risk factors influencing RR were analyzed using logistic regression.Results:After treatment with PREA,the RR of the 146 NSCLC patients was 61.64%.The differences were statistically significant when comparing age,previous treatment modality,lesion diameter,bone metastases,and tumour type between the two groups(P<0.05).Logistic regression analysis showed that Age(OR=0.351,95%CI0.145~0.852),lesion diameter(OR=0.437,95%CI 0.235~0.813),previous treatment modality(OR=3.253,95%CI 1.463~7.234),and tumour type(OR=2.970,95%CI 1.367~6.451)were independent risk factors for RR,with satistically significant difference(P<0.05).Conclusion:Age,lesion diameter,previous treatment modality and tumor type are independent factors influencing effective of PREA in the treatment of NSCLC.The clinic can combine the above factors to select the appropriate treatment plan according to the degree of patients'disease in order to control tumor progression and prolong the survival cycle.

关 键 词：癌 非小细胞肺 经皮射频消融 疗效 影响因素 

分 类 号：R730.26[医药卫生—肿瘤]