皮下持续负压引流术联合中药口服对结直肠癌患者术后切口感染率、白细胞变化及免疫功能的影响  

Effects of Subcutaneous Continuous Negative Pressure Drainage Combined with Oral Chinese Medicine on Postoperative Incision Infection Rate,Leukocyte Change and Immune Function in Patients with Colorectal Cancer

作　　者：綦声波[1] 高成业 秦万民 QI Shengbo;GAO Chengye;QIN Wanmin(Department of Gastrointestinal Surgery,Weifang Hospital of Traditional Chinese Medicine,Weifang,Shandong Province,261041 China)

机构地区：[1]潍坊市中医院胃肠外科,山东潍坊261041

出　　处：《中外医疗》2023年第19期10-13,19,共5页China & Foreign Medical Treatment

基　　金：潍坊市卫健委科研项目(WFWSJK-2021-229)。

摘　　要：目的 研究皮下持续负压引流术联合中药口服对结直肠癌患者术后切口感染率、白细胞变化及免疫功能的影响。方法 随机选取2017年1月—2021年12月潍坊市中医院收治的200例结直肠癌并且行腹腔镜手术的患者作为研究对象,按照随机数表法分为观察组和对照组,每组100例,观察组采取皮下持续负压引流术联合中药口服的治疗方式,对照组采取传统治疗方式,分析对比两组术后切口感染率、免疫功能指标、离床活动所需时间、进食恢复所需时间、住院时间、红细胞、白细胞以及血小板计数水平、血清肿瘤标志物水平等。结果 观察组术后切口感染率为2.00%,低于对照组的20.00%,差异有统计学意义(χ^(2)=16.548,P<0.05)。观察组免疫功能指标明显优于对照组,差异有统计学意义(P<0.05)。观察组离床活动所需时间、进食恢复所需时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组红细胞、白细胞以及血小板计数水平均优于对照组,差异有统计学意义(P<0.05)。观察组治疗后癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原199(carbohydrate antigen199, CA199)、糖类抗原125(carbohydrate antigen125, CA125)均低于对照组,差异有统计学意义(P<0.05)。结论 皮下持续负压引流术联合中药口服能够有效降低结直肠癌患者术后切口感染率,改善患者免疫功能,并且对降低住院时间、加快进食等均有益处。Objective To investigate the effects of subcutaneous continuous negative pressure drainage combined with oral Chinese medicine on postoperative incision infection rate,leukocyte change and immune function in patients with colorectal cancer.Methods A total of 200 patients with colorectal cancer who underwent laparoscopic surgery in Weifang Hospital of Traditional Chinese Medicine from January 2017 to December 2021 were randomly selected as the research objects.According to the random number table method,they were divided into observation group and control group,with 100 cases in each group.The observation group was treated with subcutaneous continuous negative pressure drainage combined with oral administration of traditional Chinese medicine,while the control group was treated with traditional treatment.The postoperative incision infection rate,immune function index,time required for off-bed activity,time required for eating recovery,hospitalization time,red blood cell,white blood cell and platelet count levels,and serum tumor marker levels were analyzed and compared between the two groups.Results The postoperative incision infection rate of the observation group was 2.00%,which was lower than 20.00%of the control group,and the difference was statistically significant(χ^(2)=16.548,P<0.05).The immune function index of the observation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).The time of getting out of bed,the time of eating recovery and the time of hospitalization in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).The levels of red blood cell,white blood cell and platelet count in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).After treatment,carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and carbohydrate antigen 125(CA125)in the observation group were lower than those in th

关 键 词：皮下持续负压引流术 中药口服 结直肠癌患者 切口感染率 白细胞变化 免疫功能 

分 类 号：R574.63[医药卫生—消化系统]