rtPA静脉溶栓后24 h内采取依达拉奉右莰醇注射治疗脑梗死的临床研究  

Clinical Study on Adopting Edaravone Dexborneol Injection in the Treatment of Cerebral Infarction within 24 h after Intravenous Thrombolysis by rtPA

作　　者：浦莉婷 方兰 PU Liting;FANG Lan(Department of Neurology,Xiangcheng People´s Hospital,Suzhou,Jiangsu Province,215000 China)

机构地区：[1]苏州市相城人民医院神经内科,江苏苏州215000

出　　处：《中外医疗》2023年第19期116-119,共4页China & Foreign Medical Treatment

摘　　要：目的 探讨重组组织型纤溶酶原激活剂(recombinant tissue plasminogen activator, rtPA)静脉溶栓后24 h内采取依达拉奉右莰醇注射治疗脑梗死的临床效果。方法 回顾性分析2020年5月-2022年10月期间苏州市相城人民医院接诊的79例脑梗死患者的临床资料,均进行rtPA静脉溶栓治疗,根据溶栓后24 h内采取的不同方案将其分为对照组(39例,24 h内给予肝素)和观察组(40例,24 h内给予依达拉奉右莰醇注射治疗),对比两组治疗效果,神经功能恢复情况、凝血指标等情况。结果 观察组的总有效率达到95.00%,显著高于对照组的76.92%,差异有统计学意义(χ^(2)=5.384,P<0.05)。治疗1周后及3个月后,两组NIHSS评分均降低,且观察组显著低于对照组,差异有统计学意义(P<0.05)。疗后两组患者的PT、APTT、TT均短于治疗前,且观察组显著短于对照组,差异有统计学意义(P<0.05)。结论 rtPA静脉溶栓后24 h内采取依达拉奉右莰醇注射治疗脑梗死,可进一步探讨溶栓治疗效果,有效改善患者的神经功能及凝血功能。Objective To investigate the clinical effect of edaravone dexborneol injection within 24 h after intravenous thrombolysis with recombinant tissue plasminogen activator(rtPA)in the treatment of cerebral infarction.Methods Retrospectively analyed clinical data of 79 patients with cerebral infarction admitted to Xiangcheng People's Hospital in Suzhou from May 2020 to October 2022,all of whom underwent intravenous thrombolysis with rtPA.They were divided into a control group(39 cases,given heparin within 24 hours)and an observation group(40 cases,given edaravone and camphor injection within 24 hours)based on different regimens taken within 24 hours after thrombolysis.The treatment effects,neurological function recovery,and coagulation indicators of the two groups were compared.Results The total effective rate of the observation group reached 95.00%,which was significantly higher than the control group's 76.92%,the difference was statistically significant(χ^(2)=5.384,P<0.05).After one week and three months of treatment,the NIHSS scores of both groups decreased,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of PT,APTT,and TT in both groups of patients were shorter than before treatment,and the observation group was significantly shorter than the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of cerebral infarction with edaravone dexborneol injection within 24 h after rtPA intravenous thrombolysis can further explore the effect of thrombolytic therapy,effectively improve the neurological function and coagulation function of the patients.

关 键 词：RTPA 静脉溶栓后 依达拉奉右莰醇注射液 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]