FOXD1、FOXD3蛋白在食管鳞状细胞癌中的表达及与临床特征和预后的相关性  

Expressions of forkhead box D1 and forkhead box D3 in esophageal squamous cell carcinomas and their correlation with the clinicopathological characteristics and the prognosis

作　　者：吴峥[1] 郭盛虎[1] 李文[1] 张跃华[1] 潘腾 汪治宇[1] WU Zheng;GUO Shenghu;LI Wen(Department of Immuno-oncology,the Fourth Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第四医院肿瘤免疫科,石家庄市050000

出　　处：《河北医药》2023年第16期2452-2456,共5页Hebei Medical Journal

基　　金：河北省自然科学基金精准联合基金培育项目(编号:H202206221)。

摘　　要：目的分析食管鳞癌组织中叉头框转录因子D1(FOXD1)、叉头框转录因子D3(FOXD3)的表达情况及其与临床病理特征、预后的关系。方法收集本院2011年1月至2013年12月收治的105例食管鳞癌患者临床资料。比较食管鳞癌组织及癌旁正常组织中FOXD1与FOXD3的表达情况,并分析其与临床病理特征及与患者预后的相关性。结果食管鳞癌组织中FOXD1 mRNA相对表达量高于癌旁组织,而FOXD3 mRNA相对表达量低于癌旁组织(P<0.05)。并且癌组织中FOXD1阳性表达率显著高于癌旁正常组织,FOXD3阳性表达率低于癌旁正常组织(P<0.01)。FOXD1、FOXD3表达与患者年龄、病理分化程度无关(P>0.05),与患者肿瘤TNM分期、肿瘤浸润深度以及是否合并淋巴结转移相关,差异均具有统计学意义(P<0.05)。FOXD1表达阳性以及FOXD3表达阴性是影响食管鳞癌患者总生存的独立危险因素。结论FOXD1、FOXD3在食管鳞癌组织中异常表达,其表达与肿瘤恶性生物学行为有关,二者有望成为评估患者预后的潜在分子标志物。Objective To detect expressions of forkhead box D1(FOXD1)and forkhead box D3(FOXD3)in esophageal squamous cell carcinomas(ESCC),and to identify their correlations with the prognosis and clinicopathological characteristics of ESCC patients.Methods Clinical data of 105 ESCC patients in our hospital between January 2011 and December 2013 were collected.Expressions of FOXD1 and FOXD3 in ESCC and paracancerous tissues were compared.The correlation of expressions of FOXD1 and FOXD3 with the prognosis and clinicopathological characteristics of ESCC patients was identified.Results The mRNA level of FOXD1 was significantly higher in ESCC tissues than that of paracancerous tissues,while that of FOXD3 was significantly lower(P<0.05).The positive expression rate of FOXD1 was significantly higher in ESCC tissues than that of paracancerous tissues,while that of FOXD3 was significantly lower(P<0.01).Expression levels of FOXD1 and FOXD3 were not correlated with the age and differentiation degree of ESCC patients(P>0.05),but they were significantly correlated with the tumor,node,metastasis(TNM)staging,infiltration depth and lymph node metastasis(P<0.05).The positive expression of FOXD1 and negative expression of FOXD3 were the independent risk factors for the overall survival of ESCC patients.Conclusion FOXD1 and FOXD3 are differentially expressed in ESCC,which are correlated with the malignant biological behavior.They are expected to be biomarkers for assessing the prognosis of ESCC.

关 键 词：食管鳞癌 叉头框转录因子D1 叉头框转录因子D3 预后 影响因素 

分 类 号：R735.1[医药卫生—肿瘤]