乳腺癌组织中人表皮生长因子受体-2、雌激素受体、磷酸酶张力蛋白同源物的表达及其与临床病理特征和预后的关系  

Expression of human epidermal growth factor receptor-2,estrogen receptor and phosphatase and tensin homology deleted on chromosome ten in breast cancer and their relationship with clinicopathological characteristics and prognosis

作　　者：黄晓玲 赵芳芳 陈香菊 HUANG Xiaoing;ZHAO Fangfang;CHEN Xiangju(Department of Pathology,Linfen Central Hospital,Linfen,Shanxi 041000,China)

机构地区：[1]临汾市中心医院病理科,山西临汾041000

出　　处：《现代医学与健康研究电子杂志》2023年第15期29-33,共5页Modern Medicine and Health Research

摘　　要：目的探讨乳腺癌组织中人表皮生长因子受体-2(HER-2)、雌激素受体(ER)、磷酸酶张力蛋白同源物(PTEN)的表达情况与临床病理特征的关系,以及和患者预后的关系。方法回顾性分析2018年1月至2022年1月临汾市中心医院收治的225例女性乳腺癌患者的临床资料,收集其癌旁正常组织与浸润性导管癌组织,将其分为正常组与癌化组,检测并比较两组HER-2、ER、PTEN表达情况,并分析其与患者临床病理特征的关系;随访1年,根据预后结果分为生存组(202例)与死亡组(23例),比较正常组与癌化组患者肿瘤组织HER-2、ER、PTEN表达情况;对生存组与死亡组资料进行单因素分析与多因素Logistic回归分析,筛选出影响预后生存的独立危险因素。结果癌化组HER-2和ER的阳性表达率及PTEN阴性表达率均高于正常组;HER-2、ER阳性患者中组织学分级为3级、TNM分期为Ⅲ+Ⅳ、神经/脉管侵犯、淋巴结转移患者占比高于HER-2、ER阴性患者;PTEN阳性患者中组织学分级为3级、TNM分期为Ⅲ+Ⅳ、神经/脉管侵犯、淋巴结转移均低于PTEN阴性患者;与生存组患者比,死亡组患者中组织学分级3级、TNM分期Ⅲ+Ⅳ期、神经/脉管侵犯、淋巴结转移、HER-2阳性表达、ER阳性表达、PTEN阴性表达的患者占比均更高(均P<0.05);多因素Logistic回归模型分析结果显示,组织学分级3级、TNM分期Ⅲ+Ⅳ期、神经/脉管侵犯、淋巴结转移、HER-2阳性表达、ER阳性表达、PTEN阴性表达均为影响乳腺癌患者预后生存的危险因素(OR=1.672、1.863、1.866、1.548、1.471、1.704、1.525,均P<0.05)。结论乳腺癌组织中HER-2、ER高表达,PTEN低表达,组织学分级3级、TNM分期Ⅲ+Ⅳ期、神经/脉管侵犯、淋巴结转移、HER-2阳性表达、ER阳性表达、PTEN阴性表达均为影响乳腺癌患者预后生存的危险因素,检测肿瘤组织中HER-2、ER、PTEN表达情况对乳腺癌患者治疗及预后具有重要的临床价值。Objective To explore the relationship between the expression of human epidermal growth factor receptor-2(HER-2),estrogen receptor(ER),phosphatase and tensin homology deleted on chromosome ten(PTEN)in breast cancer tissue and clinicopathological characteristics,as well as the prognosis of patients.Methods The clinical data of 225 female breast cancer patients admitted to Linfen Central Hospital from January 2018 to January 2022 were retrospectively analyzed,adjacent normal tissues and the invasive ductal carcinoma tissues were collected,and divided into the normal group and the cancerous group,the expression of HER-2,ER and PTEN and their relationship with clinicopathological features were tested and compared between the two groups;after 1 year of follow-up,the patients were divided into the survival group(202 cases)and the death group(23 cases)based on prognosis results,and the expression of HER-2,ER,and PTEN were compared between the normal group and the cancerous group;univariate analysis and multivariate Logistic regression analysis were performed on the data of the survival group and the death group in order to screen out independent risk factors affecting prognosis.Results The positive expression rate of HER-2 and ER and the negative expression rate of PTEN in the cancerous group were higher than those in the normal group;the proportion of patients with histological grading of 3 grade,TNM stage ofⅢ+Ⅳ,nerve or vascular invasion and lymph node metastasis among the patients with HER-2,ER positive expression were higher than patients with HER-2,ER negative expression;the proportion of patients with histological grading of 3 grade,TNM stage ofⅢ+Ⅳ,nerve or vascular invasion and lymph node metastasis among the patients with HER-2,ER positive expression were lower than patients with HER-2,ER negative expression;compared with patients in the survival group,the proportion of patients with histological grade 3 grade,TNM stageⅢ+Ⅳ,nerve or vascular invasion,lymph node metastasis,HER-2 positive expression,ER

关 键 词：乳腺癌 人表皮生长因子受体-2 雌激素受体 磷酸酶张力蛋白同源物 病理特征 

分 类 号：R737.9[医药卫生—肿瘤]