急性髓系白血病患者输注去白红细胞的疗效及对炎症调节因子水平的影响  

Efficacy of leukocyte-removed transfusion in patients with acute myeloid leukemia and its effect on the levels of inflammatory regulators

作　　者：陈珂 刘寅寅 刘磊[1] 朱文刚 CHEN Ke;LIU Yinyin;LIU Lei;ZHU Wengang(Fuyang People's Hospital Blood Transfusion Department,Fuyang,Anhui,China,236000)

机构地区：[1]阜阳市人民医院输血科,安徽阜阳236000

出　　处：《分子诊断与治疗杂志》2023年第8期1310-1313,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽高校自然科学研究项目(KJ2020A1030)。

摘　　要：目的研究急性髓系白血病患者输注去白红细胞的疗效及对炎症调节因子水平的影响。方法选取2020年1月至2022年8月阜阳市人民医院治疗的急性髓系白血病患者136例,对照组68例患者给予标准化疗,观察组68例患者标准化疗后输注去白红细胞。比较两组患者的疗效,免疫功能及炎症调节因子水平,不良反应情况。结果观察组缓解率80.89%,略高于对照组的75.00%,差异无统计学意义(P>0.05)。治疗前两组外周血T淋巴亚群细胞CD3+、CD4+、CD8+以及CD4+/CD8+水平比较差异无统计学意义(P>0.05),治疗后观察组的CD3+、CD4+、CD8+以及CD4+/CD8+水平均显著高于对照组,差异有统计学意义(t=4.754、5.795、5.246、2.341,P<0.05)。治疗前两组炎症调节因子白介素-6(IL-6)、白介素-10(IL-10)以及肿瘤坏死因子-α(TNF-α)水平比较差异无统计学意义(P>0.05),治疗后观察组的IL-6、IL-10以及TNF-α水平显著低于对照组,差异有统计学意义(t=12.781、4.515、8.271,P<0.05)。观察组不良反应发生率7.36%,显著低于对照组的19.12%,比较差异有统计学意义(χ^(2)=4.098,P<0.05)。结论急性髓系白血病患者标准化疗后输注去白红细胞的疗效满意,能够调节患者的免疫功能及炎症状态,安全性可靠。Objective To study the effect of transfusion of leukocyte-depleted red blood cells on the levels of inflammatory regulatory factors in patients with acute myeloid leukemia.Methods 136 patients with acute myeloid leukemia treated in Fuyang People's Hospital from January 2020 to August 2022 were selected.68 patients in the control group were given standard chemotherapy,and in the observation group,68 patients received leukocyte-removed blood transfusion after standard chemotherapy.The efficacy,immune function,levels of inflammatory regulatory factors and adverse reactions were compared between the two groups.Results The remission rate of the observation group was 80.89%,which was slightly higher than of the control group(75.00%),and the difference was not statistically significant(P>0.05).There was no significant difference in the levels of CD3+,CD4+,CD8+ and CD4+/CD8+ in peripheral blood T lymphocyte subsets between the two groups before treatment(P>0.05).After treatment,the levels of CD3+,CD4+,CD8+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group(t=4.754,5.795,5.246,2.341,P<0.05).There was no significant difference in the levels of inflammatory regulatory factors interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)between the two groups before treatment(P>0.05).After treatment,the levels of IL-6,IL-10 and TNF-α in the observation group were lower than those in the control group(t=12.781,4.515,8.271,P<0.05).The incidence of adverse reactions in the observation group was 7.36%,significantly lower than 19.12% in the control group,and the difference was statistically significant(χ^(2)=4.098,P<0.05).Conclusion The curative effect of infusion of leukocyte depletion after standard chemotherapy in patients with acute myeloid leukemia is satisfactory.It can regulate the immune function and inflammatory state of patients,and is safe and reliable.

关 键 词：急性髓系白血病 去白红细胞 炎症调节因子 T淋巴细胞 

分 类 号：R733.71[医药卫生—肿瘤]