镜像疗法联合康复训练对脑梗死偏瘫患者FMA评分、BBS评分和血清GDF-15、Fibulin-5水平的影响  

Impact of mirror therapy combined with rehabilitation training on FMA score,BBS score and serum GDF-15 and fibulin-5 levels in patients with cerebral infarction hemiplegia

作　　者：林晶晶 张肇帆 李长君 LIN Jingjing;ZHANG Zhaofan;LI Changjun(Department of Rehabilitation,Sanya Traditional Chinese Medicine Hospital,Sanya,Hainan,China,572000)

机构地区：[1]三亚市中医院康复科,海南三亚572000

出　　处：《分子诊断与治疗杂志》2023年第8期1393-1396,1401,共5页Journal of Molecular Diagnostics and Therapy

基　　金：海南省卫生健康行业科研项目(20A200020)。

摘　　要：目的观察镜像疗法(MT)联合康复训练对脑梗死偏瘫患者肢体运动功能(FMA)评分、平衡功能(BBS)评分和血清生长分化因子-15(GDF-15)、衰老关键蛋白抗原-5(Fibulin-5)水平的影响。方法选取2020年1月至2022年12月三亚市中医院收治的脑梗死偏瘫患者82例,以随机数表法分为研究组与对照组,各自41例,给予对照组患者常规治疗及康复训练,研究组在对照组基础上予以MT,两组均持续治疗3个月。比较两组临床疗效、治疗前后的FMA评分、BBS评分、下肢肌力、血清GDF-15、Fibulin-5水平。结果治疗后研究组临床疗效的总有效率为90.24%,高于对照组的73.17%,差异有统计学意义(χ^(2)=3.998,P<0.05)。治疗后两组患者上、下肢FMA评分、BBS评分、下肢肌力分级4~5级比例较治疗前增加,且研究组高于对照组,差异有统计学意义(t=2.480、2.419、2.092,Z=3.812,P<0.05)。治疗后两组患者血清GDF-15水平较治疗前降低,且研究组低于对照组,差异有统计学意义(t=2.527,P<0.05);Fibulin-5水平则较治疗前增加,且研究组高于对照组,差异有统计学意义(t=2.062,P<0.05)。结论MT联合康复训练对脑梗死偏瘫患者效果肯定,能有效促进患者躯体功能的恢复,同时有助于改善下肢肌力与血清GDF-15、Fibulin-5水平,具有临床推荐价值。Objective To observe the impact of mirror therapy(MT)combined with rehabilitation training on limb motor function(FMA)score,balance function(BBS)score and serum growth differentiation factor-15(GDF-15)and aging key protein antigen-5(fibulin-5)levels in patients with cerebral infarction hemiplegia.Methods A total of 82 patients with cerebral infarction hemiplegia admitted to Sanya Traditional Chinese Medicine Hospital from January 2020 to December 2022 were selected,and they were divided into the study group and the control group by random number table method,with 41 cases in each group.Patients in the control group were given routine treatment and rehabilitation training.Patients in the study group were given MT based on the treatment of the control group.All patients were continuously treated for 3 months.The clinical efficacy,FMA scores,BBS scores,lower limb muscle strength,serum GDF-15 and fibulin-5 levels before and after treatment were compared between the two groups.Results After treatment,the total treatment response rate in the study group was 90.24%,higher than that in the control group(73.17%),with a statistically significant difference(χ^(2)=3.998,P<0.05).After treatment,the FMA scores of upper and lower limbs,BBS scores and the proportions of grade 4-5 lower limb muscle strength in the two groups increased.These indicators in the study group were higher than those in the control group,with statistically significant differences(t=2.480,2.419,2.092,Z=3.812,P<0.05).After treatment,the serum GDF-15 levels in the two groups decreased,and the study group had lower serum GDF-15 level than the control group,with a statistically significant difference(t=2.527,P<0.05).Fibulin-5 levels in the two groups increased,and the study group had higher fibulin-5 level than the control group,with a statistically significant difference(t=2.062,P<0.05).Conclusion MT combined with rehabilitation training has a positive effect on patients with cerebral infarction hemiplegia.It can effectively promote the recovery of patients

关 键 词：镜像疗法 康复训练 脑梗死偏瘫 肢体运动功能 平衡功能 生长分化因子-15 衰老关键蛋白抗原-5 

分 类 号：R743.3[医药卫生—神经病学与精神病学]