血清CYFRA21-1、NSE、IL-6检测在肺癌辅助诊断中的价值  

Value of serum CYFRA21-1,NSE and IL-6 in auxiliary diagnosis of lung cancer

作　　者：陈敬 王艳 董青悦 CHEN Jing;WANG Yan;DONG Qingyue(Department of Oncology,Huainan East Hospital Group General Hospital,Huainan,Anhui,China,232001)

机构地区：[1]安徽生淮南市东方医院集团总医院肿瘤内科,安徽淮南232001

出　　处：《分子诊断与治疗杂志》2023年第8期1431-1434,1439,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康委科研项目(AHWJ2021a033)。

摘　　要：目的探究血清可溶性细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、白细胞介素-6(IL-6)水平在肺癌辅助诊断中的诊断价值。方法选取淮南东方医院集团2019年12月至2022年12月收治的92例肺癌患者为研究对象作为研究组,同时选取52名体检合格的同期体检者为对照组。比较两组对象的一般资料,同时比较两组对象血清中糖类抗原199(CA199)、糖类抗原153(CA153)、CYFRA21-1、NSE、IL-6的水平,分析影响肺癌的因素;通过多因素Logistic回归分析,判断肺癌发生的独立影响因素;通过受试者工作特征曲线(ROC)判断血清CYFRA21-1、NSE、IL-6及三者联合对肺癌的诊断价值。结果研究组血清CA199、CA153、CYFRA21-1、NSE、IL-6水平均高于对照组,差异有统计学意义(t=10.060、9.244、9.356、8.776、8.533,P<0.05);多因素Logistic回归分析显示,男性、吸烟、有既往肺部疾病史、粉尘环境工作史、CA199、CA153、CYFRA21-1、NSE、IL-6水平的升高是肺癌发生的独立危险因素(P<0.05);ROC曲线显示,CYFRA21-1、NSE、IL-6及三者联合检测的AUC分别为0.889、0.880、0.882、0.945,三者联合检测效果最优(P<0.05)。结论血清CYFRA21-1、NSE、IL-6联合可以有效检测肺癌,在肺癌的辅助诊断中具有重要的价值。Objective To investigate the diagnostic value of serum soluble cytokeratin 19 fragment(CYFRA21-1),neuron-specific enolase(NSE)and interleukin-6(IL-6)levels in the auxiliary diagnosis of lung cancer.Methods 92 patients with lung cancer admitted to Huainan East Hospital Group from December 2019 to December 2022 were selected as the study group,and 52 qualified physical examination subjects during the same period were selected as the control group.The general data of the two groups were compared,and the serum levels of carbohydrate antigen 199(CA199),carbohydrate antigen 153(CA153),CYFRA21-1,NSE and IL-6 were compared between the two groups,and the influencing factors of lung cancer were analyzed.The independent influencing factors of the occurrence of lung cancer were determined by multivariate Logistic regression analysis.The diagnostic value of serum CYFRA21-1,NSE,IL-6 and their combination in lung cancer was determined by receiver operating characteristic curve(ROC).Results The levels of serum CA199,CA153,CYFRA21-1,NSE and IL-6 in the study group were higher than those in the control group,and the differences were statistically significant(t=10.060,9.244,9.356,8.776,8.533,P<0.05).Multivariate Logistic regression analysis showed that Male,smoking,previous history of lung disease,dust working history,CA199,CA153,CYFRA21-1,NSE and IL-6 levels were independent risk factors for lung cancer(P<0.05).The ROC curve showed that the AUC of CYFRA21-1,NSE,IL-6 and the combined detection were 0.889,0.880,0.882 and 0.945,respectively,and the combined detection effect of CyFRA21-1,NSE and IL-6 was the highest(P<0.05).Conclusion The combination of serum CYFRA21-1,NSE and IL-6 can effectively detect lung cancer,and has important value in the auxiliary diagnosis of lung cancer.

关 键 词：可溶性细胞角蛋白19片段 神经元特异性烯醇化酶 白细胞介素-6 联合检测 肺癌诊断 

分 类 号：R734.2[医药卫生—肿瘤]