脊髓以上水平疼痛相关神经通路机制的研究进展  

Research progress on the mechanism of pain related neural pathways above the spinal cord

作　　者：陈栋洋 韩庆荣 盛海燕 CHEN Dong-Yang;HAN Qing-Rong;SHENG Hai-Yan(School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院基础医学院,新乡453003

出　　处：《生理学报》2023年第3期475-485,共11页Acta Physiologica Sinica

基　　金：supported by grants from National Natural Science Foundation of China(No.32200813);the Key Science and Technology Project of Henan Province,China(No.212102310832);Scientific Research Cultivation Project of School of Basic Medical Sciences of Xinxiang Medical University(No.JCYXYKY202106)。

摘　　要：疼痛是一种多维度的情感体验,痛感觉和痛情绪是其最主要的两个组分。关于疼痛,以往研究只专注于痛觉传递通路的某个环节或某个关键脑区,缺乏行为个体脑区与脑区连接在整体状态下参与疼痛或调节疼痛的证据。新的实验工具和实验技术的诞生,为痛感觉和痛情绪的神经通路研究带来了曙光。本文综述了近年来脊髓水平以上的神经系统(包括丘脑、杏仁核、中脑导水管周围灰质、臂旁核和内侧前额叶皮层)参与形成痛感觉和调节痛情绪的神经通路结构和功能基础,为疼痛的深入研究提供线索。Pain is a multi-dimensional emotional experience,and pain sensation and pain emotion are the two main components.As for pain,previous studies only focused on a certain link of the pain transmission pathway or a certain key brain region,and there is a lack of evidence that connectivity of brain regions is involved in pain or pain regulation in the overall state.The establishment of new experimental tools and techniques has brought light to the study of neural pathways of pain sensation and pain emotion.In this paper,the structure and functional basis of the neural pathways involved in the formation of pain sensation and the regulation of pain emotion in the nervous system above the spinal cord level,including thalamus,amygdala,midbrain periaqueductal gray(PAG),parabrachial nucleus(PB)and medial prefrontal cortex(mPFC),are reviewed in recent years,providing clues for the in-depth study of pain.

关 键 词：神经通路 痛感觉 痛情绪 行为 

分 类 号：R744[医药卫生—神经病学与精神病学]