Antimicrobial-free knitted fabric as wound dressing and the mechanism of promoting infected wound healing  

作　　者：ZHANG Huan WAN HuaKun HU XiuYuan ZHAO QingHua LU JianGuo WANG Dong LU ZhenTan 

机构地区：[1]Key Laboratory of Textile Fiber and Products(Wuhan Textile University)Ministry of Education,Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials&Application,Wuhan Textile University,Wuhan 430200,China [2]Zhende Medical Co.,Ltd.,Shaoxing 312000,China

出　　处：《Science China(Technological Sciences)》2023年第7期2147-2154,共8页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant No.51703169)。

摘　　要：Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound dressings.Two strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential biotoxicity and other side-effects.Herein,we report a new strategy for fabricating wound dressings to combat infection.Poly(4-methyl-1-pentene)(PMP) fabric can remove bacteria from infectious wounds through dressing changes based on its efficient bacterial adhesion.The maximum adhered count of S.aureus and E.coli on the PMP fabric was 1.63 × 106CFU/cm~2 and 4.77 × 105CFU/cm~2,respectively.In addition,the PMP fabric could inhibit the twitching motility of bacteria,which is beneficial for inhibiting infection.The ability of the PMP fabric to accelerate wound healing was demonstrated in vivo in a rat wound model.After treatment with the PMP fabric dressing,pathogenic bacteria in the wound were removed through dressing change;therefore,the wound exhibited better healing speed than when the commercial dressing was used.The low bacterial concentration effectively stimulated the expression of growth factors and suppressed wound inflammation,thereby accelerating wound healing.PMP fabric has three advantages:(1) it has been approved for use in clinical treatment by the Food and Drug Administration;(2) no antibacterial agent or probiotics were used;(3) the fabric could be manufactured through an industrial production process.These results indicate that the new strategy can be used in the design of new-generation wound dressings for antibacterial applications.

关 键 词：ANTI-INFECTION bacterial adhesion healing mechanism knitted fabric wound dressing 

分 类 号：TS106[轻工技术与工程—纺织工程] R318.08[轻工技术与工程—纺织科学与工程]