肿瘤标志物与肺CT对肺结节良恶性的鉴别价值研究  

Value of tumor markers and lung CT in differentiating benign from malignant pulmonary nodules

作　　者：邱艳[1] 任菁菁[1] Qiu Yan;Ren Jingjing(Department of General Practice,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院全科医学科,杭州310003

出　　处：《保健医学研究与实践》2023年第6期72-75,共4页Health Medicine Research and Practice

基　　金：浙江省医药卫生科技计划项目(2020KY136)。

摘　　要：目的通过回顾性分析探讨肿瘤标志物及肺CT对肺结节良恶性的鉴别诊断价值。方法选取2020年1月1日—12月31日杭州某医院专科收治的176例肺结节患者为研究对象,收集研究对象的病理诊断结果及其他临床资料,包括患者基本信息、血清学资料及影像学资料,分析肺CT与肿瘤标志物对肺结节性质的判断价值。结果176例肺结节患者中,65.9%为女性,最终病理诊断为恶性肺结节的患者有157例,占比89.2%。病理诊断为恶性肺结节的患者中,91.7%的最终病理组织类型为腺癌,且患者性别以女性为主。影像学诊断良性肺结节的灵敏度为10.9%,且男性(27.8%)高于女性(4.3%)(P<0.05);影像学诊断恶性肺结节的灵敏度为89.3%,诊断肺结节的整体灵敏度为60.8%。研究对象中,肺癌肿瘤标志物阳性的有47例,肺癌肿瘤标志物的灵敏度为28.0%,特异度为84.2%。结论肺结节患者以女性为主,其病理类型以腺癌为主。单独肺CT尤其肿瘤标志物对肺结节性质判断的灵敏度较低,肺部影像学诊断良性或建议随访的患者,需加强宣教,嘱患者定期检查。Objective This paper aims to investigate the value of tumor markers and lung CT in the differential diagnosis of benign and malignant pulmonary nodules.Methods A total of 176 patients with pulmonary nodules admitted to a hospital in Hangzhou from January 1 to December 31,2020,were selected as the study participants.The pathological diagnosis results and other clinical data of the participants were collected,including the basic information,serological data,and imaging data.The value of lung CT and tumor markers in judging the nature of pulmonary nodules was analyzed.Results Of the 176 ca-ses,65.9%were female,and 157(89.2%)were finally pathologically diagnosed as malignant pulmonary nodules.Of the patients with pathological diagnosis of malignant lung nodules,91.7%had adenocarcinoma as the final pathological histolog-ical type,and the gender of the patients was mainly female.The sensitivity of imaging in the diagnosis of benign pulmonary nodules was 10.9%,which was significantly higher in males than in females(27.8%vs.4.3%,P<0.05).The sensitivity of imaging in the diagnosis of malignant pulmonary nodules was 89.3%,and the overall sensitivity of pulmonary nodules in the diagnosis of pulmonary nodules was 60.8%.Among the participants,47 of whom were positive for lung cancer tumor markers,and the sensitivity and specificity of lung cancer tumor markers were 28.0%and 84.2%,respectively.Conclusion Patients with pulmonary nodules are mainly female,and adenocarcinoma acts as the main pathological type.Lung CT alone,especially tumor markers,has a low sensitivity for judging the nature of pulmonary nodules.Education needs to be strength-ened and regular examinations are advised for patients who rely on lung imaging for benign diagnosis or were given follow-up recommendations.

关 键 词：肺结节 肺腺癌 灵敏度 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]