鼓室灌注地塞米松治疗突发性耳聋的效果观察  

Therapeutic effect of intratympanic dexamethasone perfusion on sudden deafness

作　　者：黄晶晶[1] 王乐[1] 陈晓君[1] Huang Jingjing;Wang Le;Chen Xiaojun(Department of Otology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院耳科,郑州450000

出　　处：《中国实用医刊》2023年第10期94-97,共4页Chinese Journal of Practical Medicine

摘　　要：目的探究鼓室灌注地塞米松治疗突发性耳聋的效果。方法抽取2021年3月至2022年8月郑州大学第一附属医院收治的突发性耳聋患者168例,采用随机双色球法分为研究组和对照组,每组84例(84耳)。对照组患者给予静脉注射地塞米松治疗,研究组患者给予鼓室灌注地塞米松治疗。两组患者均治疗2周。比较两组患者的治疗效果,比较两组患者治疗前后听力水平(纯音听阈、低频区听阈、高频区听阈)、血管内皮功能[内皮素-1(ET-1)、脂质过氧化物(LPO)、可溶性血管细胞间黏附分子(sVCAM-1)]及血液流变学指标[纤维蛋白原(FIB)、红细胞聚集指数(EAI)、血浆黏度(PV)]。结果治疗2周后,研究组临床治疗总有效率(83.3%,70/84)高于对照组(69.0%,58/84),P<0.05。治疗2周后,两组患者纯音听阈、低频区听阈、高频区听阈及ET-1、LPO、sVCAM-1、FIB、EAI、PV水平均低于治疗前,且研究组低于对照组(P<0.05)。结论鼓室灌注地塞米松可有效改善突发性耳聋患者的听力水平,对患者血管内皮功能及血液流变学水平具有较好的调节作用,治疗效果较好。Objective To investigate the therapeutic effect of intratympanic dexamethasone perfusion on sudden deafness.Methods A total of 168 patients with sudden deafness admitted to the First Affiliated Hospital of Zhengzhou University from March 2021 to August 2022 were selected,and they were divided into study group and control group by random dichromatic sphere method,with 84 patients(84 ears)in each group.The patients in control group were treated by intravenous injection of dexamethasone,while the patients in study group were given intratympanic dexamethasone perfusion.Both groups were treated for 2 weeks.The clinical efficacy of the two groups were compared.The hearing level(pure tone threshold,low frequency tone threshold,high frequency tone threshold),vascular endothelial function assessed by endothelin-1(ET-1),lipid peroxide(LPO),soluble vascular intercellular adhesion molecule(sVCAM-1),hemorheological indicators,including fibrinogen(FIB),erythrocyte aggregation index(EAI)and plasma viscosity(PV),were compared between the two groups before and after treatment.Results After 2 weeks of treatment,the total effective rate of the study group(83.3%,70/84)was higher than that of the control group(69.0%,58/84),P<0.05.The pure tone threshold,low frequency tone threshold,high frequency tone threshold,levels of ET-1,LPO,sVCAM-1,FIB,EAI and PV in the two groups after 2 weeks of treatment were lower than those before treatment,and the above indicators in the study group were lower than those in the control group(P<0.05).Conclusions Intratympanic dexamethasone perfusion can effectively improve the hearing level of patients with sudden deafness.It has a good regulation effect on the vascular endothelial function and hemorheology level of patients,and it has good clinical therapeutic effects.

关 键 词：突发性耳聋 地塞米松 鼓室灌注 听力水平 血液流变学 血管内皮功能 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]