2型糖尿病与年龄相关性黄斑变性之间的因果关系:一项孟德尔随机化研究  

Causality between type 2 diabetes mellitus and age-related macular degeneration:a Mendelian randomization study

作　　者：刘钊 王秋元 谢仟 蔡善君 Zhao Liu;Qiu-Yuan Wang;Qian Xie;Shan-Jun Cai(Department of Ophthalmology,Affiliated Hospital of Zunyi Medical University,Guizhou Eye Hospital,Guizhou Branch of National Eye Disease Clinical Research Center,Special Key Laboratory of Ocular Diseases of Guizhou Province,Zunyi 563003,Guizhou Province,China;Zunyi Medical University,Zunyi 563003,Guizhou Province,China)

机构地区：[1]遵义医科大学附属医院眼科、贵州省眼科医院、国家眼病临床研究中心贵州省分中心、贵州省眼疾病特色重点实验室,中国贵州省遵义市563003 [2]遵义医科大学,中国贵州省遵义市563003

出　　处：《国际眼科杂志》2023年第9期1573-1577,共5页International Eye Science

基　　金：国家自然科学基金面上项目(No.31871261);贵州省科技支撑计划项目{No.黔科合支撑[2023]一般265}。

摘　　要：目的:利用双样本孟德尔随机化(MR)分析2型糖尿病(T2DM)与年龄相关性黄斑变性(ARMD)之间潜在的因果关系。方法:本研究提取FinnGen数据库中T2DM与ARMD数据,将逆方差加权(IVW)作为主要分析方法,MR-Egger回归和加权中位数(WM)作为补充方法分析二者之间的潜在关系,利用Cochran Q检验、MR-Egger回归截距进行敏感性分析,并将P值作为研究结果指标。结果:IVW分析显示,T2DM与渗出性ARMD之间存在因果关系(OR=1.14,95%CI 1.01~1.28,P=0.021),但与萎缩性ARMD的发病无明显关联(OR=0.96,95%CI 0.86~1.07,P=0.554)。敏感性分析结果证实结果不存在异质性及多效性,分析结果可靠。结论:T2DM与渗出性ARMD之间存在因果关系,由于ARMD具有高致盲率,认识和控制ARMD的危险因素对降低其患病率及早诊早治具有重要意义。AIM:To analyze the causality between type 2 diabetes mellitus(T2DM)and age-related macular degeneration(ARMD)based on two-sample Mendelian randomization(MR).METHODS:T2DM and ARMD samples were extracted from the FinnGen database.Inverse variance weighted(IVW)was used as the main analysis method,MR-Egger and weighted median(WM)as supplementary methods to analyze the potential relationship between them.In addition,Cochran Q test and MR-Egger intercept were also used to analyze the sensitivity,and the P-value was used as the index of research results.RESULTS:IVW showed that T2DM was associated with the incidence of exudative ARMD(OR=1.14,95%CI 1.01~1.28,P=0.021),but it was not significantly associated with the incidence of atrophic ARMD(OR=0.96,95%CI 0.86~1.07,P=0.554).The results of sensitivity analysis confirmed that there was no heterogeneity and pleiotropy in this study,and the results were reliable.CONCLUSION:There is a causal relationship between T2DM and exudative ARMD.Considering the high rate of blindness caused by ARMD,it is of great significance to recognize and control the risk factors of ARMD to reduce its prevalence rate and early diagnosis and treatment.

关 键 词：2型糖尿病 渗出性年龄相关性黄斑变性 萎缩性年龄相关性黄斑变性 孟德尔随机化 逆方差加权 

分 类 号：R774.5[医药卫生—眼科] R587.2[医药卫生—临床医学]