血必净注射液对重症急性胰腺炎患者血浆线粒体DNA浓度、疾病严重程度和炎症指标的影响  

Effect of Xuebijing injection on plasma mitochondrial DNA,disease severity and inflammatory markers in patients with severe acute pancreatitis

作　　者：李攀 李琼[2] 陈亮[2] 戴新贵[2] LI Pan;LI Qiong;CHEN Liang(Traditional Chinese Medicine of Jiahe,Chenzhou 423032,China)

机构地区：[1]郴州市嘉禾县中医医院,423032 [2]郴州市第一人民医院,423000

出　　处：《中国实用医药》2023年第16期6-10,共5页China Practical Medicine

基　　金：湖南省中医药研究计划项目(项目编号:2021142);国家自然科学基金(项目编号:81601708);湖南省自然科学基金(项目编号:2022JJ30092)。

摘　　要：目的探讨血必净注射液对重症急性胰腺炎(SAP)患者血浆线粒体DNA(mtDNA)、疾病严重程度及炎症指标的影响。方法选取48例符合条件的SAP患者作为研究对象,随机分为对照组(27例)和血必净组(21例)。对照组给予常规治疗,血必净组在对照组基础上给予血必净治疗。分析并比较两组患者的基本特征,比较两组患者入院时和治疗7 d后的血浆mtDNA浓度、疾病严重程度及炎症指标。结果治疗7 d后,两组患者血浆mtDNA水平均较治疗前明显下降,血必净组血浆mtDNA(7.32±1.65)ng/ml明显低于对照组的(8.43±1.65)ng/ml,差异有统计学意义(P<0.05)。治疗7 d后,两组患者急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分和序贯器官衰竭评分(SOFA)均较治疗前明显下降,血必净组APACHEⅡ评分(6.32±2.25)分、SOFA评分(2.32±0.56)分均明显低于对照组的(8.23±2.32)、(3.56±0.86)分,差异有统计学意义(P<0.05)。治疗7 d后,两组患者C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)和白细胞计数(WBC)水平均较治疗前明显下降,血必净组CRP、IL-6、PCT和WBC水平分别为(121.88±32.56)mg/L、(156.45±67.22)pg/ml、(2.72±0.53)ng/ml、(11.42±3.21)×10^(9)/L,均明显低于对照组的(153.45±46.32)mg/L、(204.34±88.45)pg/ml、(3.32±0.33)ng/ml、(15.22±3.52)×10^(9)/L,差异有统计学意义(P<0.05)。结论血必净注射液能降低SAP患者的血浆mtDNA水平,改善SAP的临床症状,对治疗SAP具有一定的临床意义。Objective To discuss the effect of Xuebijing injection on plasma mitochondrial DNA(mtDNA),disease severity and inflammatory markers in patients with severe acute pancreatitis(SAP).Methods A total of 48 eligible SAP patients were selected as the study subjects and randomly divided into control group(27 cases)and Xuebijing group(21 cases).The control group was given routine treatment,and the Xuebijing group was given Xuebijing treatment on the basis of the control group.The basic characteristics of the two groups were analyzed and compared,and the plasma mtDNA concentration,disease severity and inflammatory markers were compared between the two groups at admission and after 7 d of treatment.Results After 7 d of treatment,plasma mtDNA level in both groups were significantly lower than that before treatment in this group,and plasma mtDNA level of(7.32±1.65)ng/ml in Xuebijing group were significantly lower than that of(8.43±1.65)ng/ml in the control group.The differences were statistically significant(P<0.05).After 7 d of treatment,the scores of Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)and Sequential Organ Failure Assessment(SOFA)in both groups were significantly lower than those before treatment in this group;APACHEⅡscore of(6.32±2.25)points and SOFA of(2.32±0.56)points in Xuebijing group were significantly lower than those of(8.23±2.32)and(3.56±0.86)points in the control group;the differences were statistically significant(P<0.05).After 7 d of treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)and white blood cell count(WBC)in both groups were significantly decreased compared with those before treatment in this group;the levels of CRP,IL-6,PCT and WBC were(121.88±32.56)mg/L,(156.45±67.22)pg/ml,(2.72±0.53)ng/ml and(11.42±3.21)×10^(9)/L in Xuebijing group,which were significantly lower than those of(153.45±46.32)mg/L,(204.34±88.45)pg/ml,(3.32±0.33)ng/ml and(15.22±3.52)×10^(9)/L in the control group;the differences were statistically significant(P<

关 键 词：重症急性胰腺炎 线粒体DNA 血必净注射液 疾病严重程度 炎症指标 

分 类 号：R576[医药卫生—消化系统]