黄芩苷联合甲硝唑对胃火肾虚型牙周炎患者牙周指数及炎性因子的影响  

Effect of baicalin combined with metronidazole on periodontal index and inflammatory factors in patients with gastric fire and kidney deficiency type periodontitis

作　　者：夏琳[1] 徐东升[1] 张彬 柏忠英 袁玲 吴晨[1] XIA Lin;XU Dong-sheng;ZHANG Bin(Department of Stomatology,Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201900,China)

机构地区：[1]上海中医药大学附属宝山医院,201900

出　　处：《中国实用医药》2023年第16期11-16,共6页China Practical Medicine

基　　金：上海市卫生健康委员会科研课题(项目编号:202040466)。

摘　　要：目的探讨黄芩苷联合甲硝唑对胃火肾虚型牙周炎患者牙周指数及炎性因子的影响,以期为临床治疗方法的选择提供参考。方法120例胃火肾虚型牙周炎患者,按照随机数字表法分为空白对照组、甲硝唑组、黄芩苷联用甲硝唑组,每组40例。三组患者均给予系统治疗,在此基础上,空白对照组患者不使用任何口服药及局部用药,甲硝唑组患者接受甲硝唑治疗,黄芩苷联用甲硝唑组患者接受黄芩苷联合甲硝唑治疗。比较三组临床疗效及治疗前后牙周指数指标、血清炎症因子水平、龈沟液中氧化应激指标。结果三组临床总有效率比较差异具有统计学意义(P<0.05)。黄芩苷联用甲硝唑组总有效率95.00%高于甲硝唑组的75.00%和空白对照组的40.00%,甲硝唑组高于空白对照组,差异具有统计学意义(P<0.05)。治疗后,三组牙周探诊深度(PD)、龈沟出血指数(SBI)、附着水平(AL)比较差异具有统计学意义(P<0.05)。治疗后,甲硝唑组、黄芩苷联用甲硝唑组PD、SBI、AL均明显低于本组治疗前,差异具有统计学意义(P<0.05)。治疗后,黄芩苷联用甲硝唑组PD(2.14±0.28)mm、SBI(1.24±0.30)分、AL(3.14±1.22)mm均明显低于甲硝唑组的(2.87±0.37)mm、(1.97±0.42)分、(3.78±1.34)mm和空白对照组的(5.25±1.82)mm、(3.64±0.43)分、(4.47±1.52)mm,甲硝唑组明显低于空白对照组,差异具有统计学意义(P<0.05)。治疗后,三组肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、白细胞介素-1β(IL-1β)水平比较差异具有统计学意义(P<0.05)。治疗后,甲硝唑组、黄芩苷联用甲硝唑组TNF-α、PCT、IL-1β水平均明显低于本组治疗前,差异具有统计学意义(P<0.05)。治疗后,黄芩苷联用甲硝唑组TNF-α(5.16±1.24)μg/L、PCT(5.23±1.93)ng/L、IL-1β(5.37±1.96)pg/ml均明显低于甲硝唑组的(9.23±3.14)μg/L、(8.85±2.12)ng/L、(6.92±1.04)pg/ml和空白对照组的(13.92±5.20)μg/L、(16.14±6.30)ng/L、(8.66±2.89)pg/ml,甲�Objective To discuss the effect of baicalin combined with metronidazole on periodontal index and inflammatory factors in patients with gastric fire and kidney deficiency type periodontitis,so as to provide reference for the selection of clinical treatment.Methods A total of 120 patients with gastric fire and kidney deficiency type periodontitis were divided into blank control group,metronidazole group and baicalin with metronidazole group according to random numerical table,with 40 cases in each group.All patients in the three groups were given systematic treatment.On this basis,patients in the blank control group were not given any oral or local medication,patients in the metronidazole group received metronidazole treatment,and patients in the baicalin with metronidazole group received baicalin combined with metronidazole treatment.The clinical efficacy,periodontal index indexes before and after treatment,serum inflammatory factor levels,oxidative stress indexes in gingival crevicular fluid before and after treatment were compared among the three groups.Results The total clinical effective rate of the three groups was compared,and the difference was statistically significant(P<0.05).The total effective rate of 95.00%in baicalin with metronidazole group was higher than that of 75.00%in metronidazole group and 40.00%in blank control group;the metronidazole group was higher than the blank control group;the difference was statistically significant(P<0.05).After treatment,the differences in periodontal probing depth(PD),gingival sulcus bleeding index(SBI),and attachment level(AL)among the three groups were statistically significant(P<0.05).After treatment,PD,SBI and AL in metronidazole group and baicalin with metronidazole group were significantly lower than those before treatment in this group,and the differences were statistically significant(P<0.05).After treatment,baicalin with metronidazole group had PD of(2.14±0.28)mm,SBI of(1.24±0.30)min and AL of(3.14±1.22)mm,which were significantly lower than those of(2.

关 键 词：黄芩苷 甲硝唑 胃火肾虚型牙周炎 牙周指数 炎性因子 

分 类 号：R781.42[医药卫生—口腔医学]