阿尔茨海默病中β-淀粉样蛋白异常沉积机制的研究进展  

Recent advance in mechanism of abnormalβ-amyloid deposition in Alzheimer's disease

作　　者：卢硕 肖怡 葛丽特 卢明[1] Lu Shuo;Xiao Yi;Ge Lite;Lu Ming(Department of Neurosurgery,Second Affiliated Hospital of Hunan Normal University(The 921 Hospital of PLA),Changsha 410003,China;Hunan Provincial Key Laboratory of Neuroprosthetics,Changsha 410003,China;Department of Neurology,Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]湖南师范大学第二附属医院(解放军第九二一医院)神经外科,长沙410003 [2]神经修复学湖南省重点实验室,长沙410003 [3]中南大学湘雅二医院神经内科,长沙410011

出　　处：《中华神经医学杂志》2023年第6期627-630,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金青年项目(82201484);湖南省重点研发计划项目(2020SK2102);湖南省研究生科研创新项目(CX20220528)。

摘　　要：近年研究发现,AD中神经元受损事件要先于β-淀粉样蛋白(Aβ)的异常沉积,Aβ斑块可能并不是AD发病的直接病因,而只是AD发病后的病理表现,但是Aβ异常沉积与AD联系紧密,因此探讨AD中Aβ的异常沉积机制对于AD的早期诊治仍具有重要意义。Aβ的异常沉积已被证实与自噬功能障碍、细胞焦亡、铁死亡和脑膜淋巴管(Mlvs)回流障碍密切相关,故本文现围绕上述病理过程对AD发生中Aβ斑块异常沉积的作用综述如下,以期寻找新的AD干预靶点。Recent studies have found that neuronal damage events precede abnormal deposition ofβ-amyloid(Aβ),and Aβplaques may not be the direct cause of AD,but only the pathological manifestation of AD,but abnormal Aβdeposition is closely related to AD,so it is important to explore the mechanism of abnormal Aβdeposition in diagnosis and treatment of AD.The abnormal Aβdeposition has been linked to autophagy dysfunction,pyroptosis,ferroptosis and meningeal lymphatic vessels(Mlvs)reflux disorder,therefore,this paper reviews the roles of autophagy dysfunction,pyroptosis,ferroptosis and Mlvs reflux disorder in abnormal Aβdeposition during AD,aiming to find new targets for AD intervention.

关 键 词：阿尔茨海默病 Β-淀粉样蛋白 自噬 细胞焦亡 铁死亡 脑膜淋巴管 

分 类 号：R749.16[医药卫生—神经病学与精神病学]