脑积水动物模型的研究进展  

Recent advance in animal model of hydrocephalus

作　　者：邓学海 李杭洋 丁建林 黄兴元 陈鑫龙 赵龙[1] Deng Xuehai;Li Hangyang;Ding Jianlin;Hang Xingyuan;Chen Xinlong;Zhao Long(Neurosurgery Laboratory,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;School of Clinical Medicine,North Sichuan Medical College,Nanchong 637199,China;School of Mental Health,North Sichuan Medical College,Nanchong 637199,China)

机构地区：[1]川北医学院附属医院神经外科研究室,南充637000 [2]川北医学院临床医学院,南充637199 [3]川北医学院精神卫生学院,南充637199

出　　处：《中华神经医学杂志》2023年第6期636-641,共6页Chinese Journal of Neuromedicine

基　　金：四川省大学生创新创业训练计划项目(S202210634079);川北医学院科研发展计划(CBY20-QA-Z02)。

摘　　要：脑积水动物模型是研究脑积水发生发展机制、病理特征及治疗方法的重要对象,构建稳定可控且符合脑积水临床发展规律的动物模型有助于促进脑积水相关基础研究的发展与临床转化应用。根据研究目的和实验动物的遗传及生理特点的不同,目前已有多种动物被用于建立不同类型的脑积水动物模型,其中先天性脑积水建模方法包括基因编辑、代谢诱导等,继发性脑积水模型的构建则可采用阻塞脑脊液循环通路、干扰脑脊液吸收机制等方法,不同方法构建的脑积水动物模型在病程进展、神经功能改变、组织病理特点等方面各不相同。本文对各类脑积水动物模型的构建方法及其病理特征予以综述,以期为脑积水相关研究中动物模型的选择提供参考。Animal model of hydrocephalus is an important object to study the mechanism,pathological characteristics,and treatment of hydrocephalus.A stable and controllable animal model in accordance with clinical development of hydrocephalus can help to develope hydrocephalus related basic research and clinical translational application.According to the study purpose and genetic and physiological characteristics of experimental animals,a variety of animals have been used to establish different types of hydrocephalus animal models.The methods for congenital hydrocephalus models include gene edition and metabolic induction,while secondary hydrocephalus models can be induced by blocking the circulation of cerebrospinal fluid and interfering cerebrospinal fluid absorption.The hydrocephalus models constructed by different methods are also different in progression,neurofunctional changes,and histopathological characteristics.This paper reviews the construction methods and pathological characteristics of various hydrocephalus models in order to provide references for selection of animal models for hydrocephalus-related research.

关 键 词：先天性脑积水 继发性脑积水 动物模型 

分 类 号：R-332[医药卫生] R742.7