急性后循环脑梗死患者椎动脉颅内段钙化特征与中医体质分型相关性研究  

Study on the correlation between the characteristics of intracranial vertebral artery calcification and TCM constitution classification in patients with acute posterior circulation cerebral infarction

作　　者：郭泽春 姜燕 郑峰 闫瑾 柳淑青 袁杰 李佳勇 许长敏 GUO Zechun;JIANG Yan;ZHENG Feng;YAN Jin;LIU Shuqing;YUAN Jie;LI Jiayong;XU Changmin(Department of Neurology,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院神经内科,北京101300 [2]上海中医药大学继续教育学院,上海201203 [3]北京中医医院顺义医院康复科,北京101300

出　　处：《陕西中医》2023年第9期1212-1215,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81804090);北京市属医院科研培育计划项目(PZ2023023)。

摘　　要：目的:分析急性后循环脑梗死(APCCI)患者椎动脉颅内段(IVA)钙化特征与中医体质分型相关性研究。方法:选择100例急性脑血管疾病患者,所有患者均进行椎动脉及颅脑CT检查,并分成APCCI组(n=50)、非APCCI组(n=50),对比两组IVA钙化情况,并分析APCCI患者中医体质分布规律;对比不同中医体质分型APCCI患者IVA钙化情况,采用Spearman分析APCCI患者IVA钙化特征与中医体质分型的相关性;进一步比较两组临床指标,并采用多因素回归分析法分析影响APCCI患者IVA钙化的危险因素。结果:APCCI患者IVA钙化率明显高于非APCCI患者;APCCI患者常见的中医体质为痰湿质、气虚质,分别占比32.00%、28.00%;不同中医体质分型的APCCI患者IVA钙化情况不同或不完全相同;而Spearman分析发现APCCI患者中医体质分型与IVA钙化存在一定相关性(r=0.413,P<0.05);钙化组UA、HDL-C、ALP高于无钙化组(P<0.05),两组在年龄、性别、吸烟情况、基础病史等方面比较差异无统计学意义(P>0.05);经Logistic回归分析发现,UA、ALP、HDL-C是影响APCCI患者IVA钙化的确切性风险因素。结论:APCCI患者IVA钙化与中医体质分型有一定相关性,且影响APCCI患者IVA钙化的因素较多,需进一步加强APCCI防治工作。Objective:To analyze the correlation between vertebral artery intracranial segment(IVA)calcification and TCM constitution classification in patients with acute posterior circulation cerebral infarction(APCCI).Methods:A total of 100 patients with acute cerebrovascular diseases were selected.All patients underwent vertebral artery and craniocerebral CT examination,and were divided into APCCI group(n=50)and non-APCCI group(n=50).IVA calcification in the two groups was compared and analyzed.The distribution law of TCM constitution of APCCI patients was analyzed.According to the IVA calcification of APCCI patients,they were divided into calcification group and non-calcification group.The IVA calcification of APCCI patients with different TCM constitution types was compared,and the correlation between the IVA calcification characteristics of APCCI patients and TCM constitution types was analyzed by Spearman.The clinical indicators of the two groups were further compared and the risk factors of IVA calcification in APCCI patients were analyzed by multivariate regression analysis.Results:The rate of IVA calcification in APCCI patients was significantly higher than that in non-APCCI patients.The common constitutions of TCM in APCCI patients were phlegm-dampness and qi-deficiency,accounting for 32.00%and 28.00%respectively.IVA calcification of APCCI patients with different TCM constitution types was different or not identical;Spearman analysis found that there was a correlation between TCM constitution classification and IVA calcification in APCCI patients(r=0.413,P<0.05).The UA,HDL-C and ALP of the calcification group were higher than those of the non-calcification group(P<0.05),and there were no statistically significant differences in age,sex,smoking status and basic medical history between the two groups(P>0.05).Logistic regression analysis showed that UA,ALP and HDL-C were the exact risk factors affecting IVA calcification in APCCI patients.Conclusion:IVA calcification in APCCI patients has a certain correlation with

关 键 词：急性后循环脑梗死 椎动脉颅内段 钙化特征 中医体质分型 相关性分析 危险因素分析 

分 类 号：R743.34[医药卫生—神经病学与精神病学]