胆汁酸代谢及其受体调节溃疡性结肠炎肠道免疫及中药干预研究进展  

Research progress on bile acid metabolism and its receptors regulating intestinal immunity in ulcerative colitis and traditional Chinese herbal medicine intervention

作　　者：干丹 杨豪杰[1] 黄冕 李盈[1] 崔灿[1] 蒋嘉奇 尹相宜 王振宜[1] GAN Dan;YANG Haojie;HUANG Mian;LI Ying;CUI Can;JIANG Jiaqi;YIN Xiangyi;WANG Zhenyi(Department of Anorectology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院肛肠科,上海200437

出　　处：《上海中医药杂志》2023年第9期96-100,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81973859);上海市卫健委中医药科研项目(2020JQ006);上海中医药大学附属岳阳中西医结合医院青年孵育项目(2019YYQ26)。

摘　　要：溃疡性结肠炎(UC)是一种慢性免疫介导的肠道炎症性疾病,由宿主遗传、环境因素和肠道菌群失调等因素相互作用引起,有导致结直肠癌的风险。特定细菌代谢产物胆汁酸可作为信号转导分子影响机体对肠道炎症的敏感性,胆汁酸信号转导异常可能是UC免疫反应失调的促成因素。近年来,中药(单味中药或其提取物、中药药对、中药复方)干预胆汁酸代谢及其受体的研究颇受关注。综述胆汁酸代谢及其受体调节UC肠道免疫研究进展,以及中药对胆汁酸代谢及其受体的干预作用,以期为UC的临床诊疗提供思路。Ulcerative colitis(UC)is a chronic immune-mediated intestinal inflammatory disease caused by complex interactions among host genetic risk factors,environmental factors and gut microbiota imbalance,and can increase the risk of colorectal cancer.Specific bacterial metabolites,bile acids,can act as signal transduction molecules that affect the susceptibility of the host to intestinal inflammation.Dysregulated bile acid signaling may contribute to the dysregulation of the immune response in UC patients.In recent years,there has been considerable interest in the study of traditional Chinese herbal medicines(single herbs or extracts,herbal pairs and herbal formulas)interfering with bile acid metabolism and its receptors.We review the advances in the studies of bile acid metabolism and its receptors regulating intestinal immunity in UC patients and the intervention of traditional Chinese herbal medicines on bile acid metabolism and its receptors in order to provide ideas for the clinical treatment of ulcerative colitis.

关 键 词：溃疡性结肠炎 胆汁酸 代谢产物 肠道菌群 肠道免疫 中药 

分 类 号：R574.62[医药卫生—消化系统]