基质细胞衍生因子1/CXC趋化因子受体4轴在骨免疫相关疾病中的研究进展  

Research progress of stromal cell derived factor-1/CXC-chemokine receptor 4 axis in bone-immune related diseases

作　　者：罗皓天 陈丹莹 王伟财[1] 周晨[1] Haotian Luo;Danying Chen;Weicai Wang;Chen Zhou(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2023年第3期218-227,共10页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：国家自然科学基金(82001005、82201095);广东省基础与应用基础研究基金(2021A1515110303);广州市科技计划(202102021198)。

摘　　要：骨免疫学是一个将骨生物学和免疫学领域结合起来的跨学科领域,近年来受到了学者的关注和深入探索。基质细胞衍生因子1(SDF-1)是一种趋化因子,影响各种生理途径。CXC趋化因子受体4(CXCR4)在各系统的细胞中广泛表达,参与机体生理及病理过程。在骨免疫疾病中,CXCR4与SDF-1结合并激活下游信号通路,在血管生成、免疫反应、骨吸收与骨生成中发挥着重要的作用。本文拟阐述目前SDF-1/CXCR4轴在骨免疫系统中的作用与机制,及其在骨免疫相关疾病中的研究进展,并探讨其在未来的发展前景。Osteoimmunology is an interdisciplinarity which combines the fields of bone biology and immunology,and has been paid close attention to and deeply explored by scholars in recent years.Stromal cell derived factor-1(SDF-1)is a chemokine that affects various physiological pathways.CXC-chemokine receptor 4(CXCR4)is widely expressed in cells of various systems and participates in physiological and pathological processes.In bone-immune diseases,CXCR4 binds to SDF-1 and subsequently activates downstream signaling pathways,which plays an important role in angiogenesis,immune response,bone resorption and bone formation.In this review,the functions and mechanisms of SDF-1/CXCR4 axis in bone-immune system,its research progress in bone-immune related diseases as well as its prospect in the future were discussed.

关 键 词：基质细胞衍生因子1 受体 CXCR4 炎症反应 骨疾病 骨免疫 

分 类 号：R78[医药卫生—口腔医学]