缺血性脑卒中神经元死亡机制  

Mechanism of neuronal death in ischemic stroke

作　　者：王漫漫 张勇[2] 付雪琴 邹旭欢 王玮玮 王保奇[3] 兰瑞[3] WANG Man-man;ZHANG Yong;FU Xue-qin;ZOU Xu-huan;WANG Wei-wei;WANG Bao-qi;LAN Rui(Fisrt Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Dept of Traditional Chinese Medicine,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Dept of Encephalopachy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450099,China)

机构地区：[1]河南中医药大学第一临床医学院,河南郑州450046 [2]郑州大学第三附属医院中医科,河南郑州450052 [3]河南中医药大学第一附属医院脑病科,河南郑州450099

出　　处：《中国药理学通报》2023年第9期1627-1632,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81973618,81503422);河南省自然科学基金资助项目(No 202300410399)。

摘　　要：脑卒中为全球第二大死亡原因,其中60%~80%为缺血性脑卒中。缺血性脑卒中发生后会不可避免引起核心区域神经元的损伤,随着缺血时间的增加,缺血半暗带的其他神经元也会因失去“信号连接”而死亡,并进一步引发机体功能障碍。鉴于缺血性脑卒中发生后神经元死亡机制的复杂性,了解死亡机制的作用原理,可以更好地挽救缺血半暗带神经元细胞。该综述针对几种主要的缺血性脑卒中神经元死亡机制及其潜在治疗靶点进行阐述,为作用机制研究的进一步完善和药物的开发提供依据和帮助。Stroke is the second leading cause of death in the world,of which about 60%-80%are ischemic stroke.Ischemic stroke will inevitably cause the damage of neurons in the core area.With the increase of ischemic time,other neurons in the ischemic penumbra will also die due to the loss of“signal connection”,and further lead to body dysfunction.In view of the complexity of neuronal death mechanism after ischemic stroke,understanding the action principle of death mechanism can better save ischemic penumbra neurons.This review mainly expounds several main mechanisms and potential therapeutic targets of neuronal death after ischemic stroke,so as to provide basis and help for the improvement of action mechanism research and drug development.

关 键 词：缺血性脑卒中 神经元 机制 潜在治疗靶点 凋亡 自噬 铁死亡 

分 类 号：R-05[医药卫生] R322.81R329.25R743.31