Venous thromboembolism in patients with liver cancer:a retrospective study  

作　　者：Sheng-Li Yang Jing Zhan Miao Peng Ling-Zhi Hou Qiu-Yi He Hao-Ran Jin Bai Wei Jian-Li Hu 

机构地区：[1]Cancer Center,Union Hospital,Tongji Medical Col ege,Huazhong University of Science and Technology [2]Division of Oncology,Tianyou Hospital affiliated to Wuhan University of Science and Technology [3]Tongji Medical College,Huazhong University of Science and Technology [4]Division of Oncology,Liyuan Hospital,Tongji Medical Col ege,Huazhong University of Science and Technology

出　　处：《Oncology and Translational Medicine》2023年第4期184-188,共5页肿瘤学与转化医学（英文版）

基　　金：approved by the Ethics Committee of Union Hospital,Huazhong University of Science and Technology,China(No.S810).

摘　　要：Background:Little is known about the association between venous thromboembolism(VTE)and tumors.In this study,we identified the clinical features of patients with liver cancer who presented with at least 1 VTE episode.Methods:This was a retrospective case-control study of a single-institution database with univariate and multivariate analyses usingχ^(2)and Fisher exact tests.Statistical significance was set at P<0.05.Results:The overall incidence of VTE in the patients with liver cancer was 1.2%.More than half(53.8%)of the 13 patients with liver cancer and venous thrombosis died within 2 months.The thrombus in 12 patients(92.3%)was located within the deep veins,whereas the other patient(7.7%)was diagnosed with a pulmonary embolism.Of the 11 patients,9(69.2%)had swelling and/or pain symptoms.All 6 patients with peripherally inserted central catheters(PICCs)had thrombosis,accounting for 46.2%of all patients with liver cancer and venous thrombosis.Compared with the controls,liver cancer patients with PICC tubes,thrombosis-related symptoms such as swelling and pain,traumatic stimulation such as fracture,acute respiratory distress syndrome,and interventional therapy or hemostasis drugs were prone to be diagnosed with VTE(P<0.05).Conclusions:Liver cancer and thrombosis are rare and have poor prognoses.Liver cancer with thrombosis may be associated with PICC catheterization,traumatic stimulation,or hemostatic drugs.Patients with liver cancer and thrombosis often present with swelling and pain.

关 键 词：Liver cancer THROMBUS Deep vein thrombosis Peripherally inserted central catheter(PICC)catheterization 

分 类 号：R735.7[医药卫生—肿瘤]